COPD: Medical Nutrition Therapy (2019)
Author and Year:
McDonald V et al 2016
PubMed ID:
Article Title:
Should we treat obesity in COPD? The effects of diet and resistance exercise training.
Authors:
McDonald V, Gibson P, Scott H, Baines P, Hensley M, Pretto J, Wood L
Journal:
Respirology (Carlton, Vic.)
Year of publication:
2016
Volume:
21
Issue:
5
Page numbers:
875-82
Study Design:
Before-After Study
Risk of Bias Assessment Rating:
Positive
Inclusion Criteria:
Obese (BMI >=30 kg/m2); COPD patients from respiratory clinics of the John Hunter Hospital, Newcastle, Australia;
COPD partients defined by a post-bronchodilator forced expiratory volume in 1 second (FEV1) <80% predicted and a forced expiratory ratio <0.70; Satisfactory written and verbal English language skills; A Mini Mental State Examination score >24; Demonstrate readiness to change; At the time of recruitment, in a stable disease state, defined as not having required antibiotics or oral corticosteroids for an acute exacerbation within the previous month
Exclusion Criteria:
Current smokers; untreated cardiac arrhythmias; unstable angina; congestive heart failure; renal or hepatic failure;
acute pancreatitis; acute oedema; prescribed insulin; specialized dietary plan for another medical condition; unexplained change in weight (±5% body weight) in the previous 3 months; significant orthopaedic problems that would compromise the capacity to exercise
Research Purpose:
To test the hypothesis that in COPD patients, weight reduction involving a low-energy diet coupled with resistance training would improve COPD clinical outcomes and reduce systemic inflammation whilst maintaining skeletal muscle mass.
Blinding efforts:
Not applicable
Study Location:
Respiratory Clinics of the John Hunter Hospital, Newcastle, Australia
Source(s) of Funding:
Charitable Trust
Please specify names of funders:
John Hunter Hospital Charitable Trust Research Grants Scheme
Quality Criteria Checklist: Primary Research
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Relevance Questions | |||
1. | Would implementing the studied intervention or procedure (if found successful) result in improved outcomes for the patients/clients/population group? (Not Applicable for some epidemiological studies) | Yes | |
2. | Did the authors study an outcome (dependent variable) or topic that the patients/clients/population group would care about? | Yes | |
3. | Is the focus of the intervention or procedure (independent variable) or topic of study a common issue of concern to dieteticspractice? | Yes | |
4. | Is the intervention or procedure feasible? (NA for some epidemiological studies) | Yes | |
Validity Questions | |||
1. | Was the research question clearly stated? | Yes | |
1.1. | Was (were) the specific intervention(s) or procedure(s) [independent variable(s)] identified? | Yes | |
1.2. | Was (were) the outcome(s) [dependent variable(s)] clearly indicated? | Yes | |
1.3. | Were the target population and setting specified? | Yes | |
2. | Was the selection of study subjects/patients free from bias? | Yes | |
2.1. | Were inclusion/exclusion criteria specified (e.g., risk, point in disease progression, diagnostic or prognosis criteria), and with sufficient detail and without omitting criteria critical to the study? | Yes | |
2.2. | Were criteria applied equally to all study groups? | Yes | |
2.3. | Were health, demographics, and other characteristics of subjects described? | Yes | |
2.4. | Were the subjects/patients a representative sample of the relevant population? | No | |
4. | Was method of handling withdrawals described? | Yes | |
4.1. | Were follow-up methods described and the same for all groups? | Yes | |
4.2. | Was the number, characteristics of withdrawals (i.e., dropouts, lost to follow up, attrition rate) and/or response rate (cross-sectional studies) described for each group? (Follow up goal for a strong study is 80%.) | Yes | |
4.3. | Were all enrolled subjects/patients (in the original sample) accounted for? | Yes | |
5. | Was blinding used to prevent introduction of bias? | Yes | |
5.2. | Were data collectors blinded for outcomes assessment? (If outcome is measured using an objective test, such as a lab value, this criterion is assumed to be met.) | Yes | |
6. | Were intervention/therapeutic regimens/exposure factor or procedure and any comparison(s) described in detail? Were interveningfactors described? | Yes | |
6.3. | Was the intensity and duration of the intervention or exposure factor sufficient to produce a meaningful effect? | Yes | |
6.4. | Was the amount of exposure and, if relevant, subject/patient compliance measured? | Yes | |
6.5. | Were co-interventions (e.g., ancillary treatments, other therapies) described? | Yes | |
7. | Were outcomes clearly defined and the measurements valid and reliable? | Yes | |
7.1. | Were primary and secondary endpoints described and relevant to the question? | Yes | |
7.2. | Were nutrition measures appropriate to question and outcomes of concern? | Yes | |
7.3. | Was the period of follow-up long enough for important outcome(s) to occur? | No | |
7.4. | Were the observations and measurements based on standard, valid, and reliable data collection instruments/tests/procedures? | Yes | |
7.5. | Was the measurement of effect at an appropriate level of precision? | Yes | |
7.6. | Were other factors accounted for (measured) that could affect outcomes? | Yes | |
8. | Was the statistical analysis appropriate for the study design and type of outcome indicators? | Yes | |
8.1. | Were statistical analyses adequately described and the results reported appropriately? | Yes | |
8.2. | Were correct statistical tests used and assumptions of test not violated? | Yes | |
8.3. | Were statistics reported with levels of significance and/or confidence intervals? | Yes | |
8.4. | Was "intent to treat" analysis of outcomes done (and as appropriate, was there an analysis of outcomes for those maximally exposed or a dose-response analysis)? | No | |
8.5. | Were adequate adjustments made for effects of confounding factors that might have affected the outcomes (e.g., multivariate analyses)? | No | |
8.6. | Was clinical significance as well as statistical significance reported? | Yes | |
8.7. | If negative findings, was a power calculation reported to address type 2 error? | N/A | |
9. | Are conclusions supported by results with biases and limitations taken into consideration? | Yes | |
9.1. | Is there a discussion of findings? | Yes | |
9.2. | Are biases and study limitations identified and discussed? | Yes | |
10. | Is bias due to study's funding or sponsorship unlikely? | Yes | |
10.1. | Were sources of funding and investigators' affiliations described? | Yes | |
10.2. | Was the study free from apparent conflict of interest? | Yes | |