MNT: Lipid Profile (2022)
Author and Year:
Tonstad S, Sundfør T, Seljeflot I 2005
PubMed ID:
Article Title:
Effect of lifestyle changes on atherogenic lipids and endothelial cell adhesion molecules in young adults with familial premature coronary heart disease.
Authors:
Tonstad S, Sundfør T, Seljeflot I
Journal:
The American Journal of Cardiology
Year of publication:
2005
Volume:
95
Issue:
10
Page numbers:
1187-1191
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Low
Inclusion Criteria:
Eligible subjects had a fasting cholesterol concentration of 5 to 8 mmol/L with at least 1 of the following lipid abnormalities: a concentration of low-density lipoprotein (LDL) cholesterol greater than 4 mmol/L, triglycerides at or greater than 1.5 mmol/L, high-density lipoprotein (HDL) cholesterol less than 1.0 mmol/L (men) or less than 1.2 mmol/L (women), or lipoprotein(a) that was greater than 75th percentile. Subjects had a family history of premature CHD defined as a first-degree relative with premature CHD (men at less than 60 years or women at less than 65 years) or at least 1 first degree relative with hyperlipidemia (cholesterol greater than 7.8 mmol/L or triglycerides greater than 2 mmol/L, or both), and a second-degree relative with premature CHD. CHD before age 60 years, rather than the conventional limit of 55 years.
Exclusion Criteria:
Subjects with a high risk of CHD, including those with a history of any cardiovascular disease, diabetes, familial hypercholesterolemia (based on a positive deoxyribonucleic acid analysis), a cholesterol level greater than 8 mmol/L, or body mass index (BMI) greater than 40 kg/m2, were excluded. In addition, subjects following vegan or unusual diets (none excluded) or with secondary hyperlipidemia or pharmacologically treated hypothyroidism, hypertension, or hyperlipidemia were excluded.
Research Purpose:
The objective of this study was to evaluate the effects of a lifestyle modification program on lipids and novel risk markers in young relatives of patients with premature CHD.
Blinding efforts:
Subjects were randomly allocated to an intensified lifestyle change group or a control group using sealed, consecutively numbered opaque envelopes. No other mention of blinding efforts.
Study Location:
Ullevål University Hospital, Oslo, Norway
Source(s) of Funding:
Not-for-profit
Please specify names of funders:
Norwegian Foundation for Health and Rehabilitation, Oslo, Norway