T1DM: Vitamin D Supplementation (2023)
Author and Year:
Sharma S, Biswal N, et al. 2017
PubMed ID:
Article Title:
Does Vitamin D Supplementation Improve Glycaemic Control In Children With Type 1 Diabetes Mellitus? - A Randomized Controlled Trial.
Authors:
Sharma S, Biswal N, Bethou A, Rajappa M, Kumar S, Vinayagam V
Journal:
Journal of Clinical and Diagnostic Research
Year of publication:
2017
Volume:
11
Issue:
9
Page numbers:
SC15-SC17
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Low risk
Inclusion Criteria:
Children aged 1-18 years with T1DM attending the Paediatric endocrinology clinic were enrolled.
Confirmation of Type 1 diabetes was based on: dependence on insulin for diabetes control from time of diagnosis, diabetic ketoacidosis or marked ketonuria at time of clinical onset, lack of obesity, and lack of Acanthosis Nigricans
Exclusion Criteria:
Those with one or more of the following criteria were excluded: children on Vitamin D supplements for one month preceding; malabsorption syndrome; primary or secondary immunodeficiency, renal stones; chronic kidney disease, adrenal tumours and children on steroid therapy for more than 2 weeks.
Research Purpose:
To evaluate the role of Vitamin D as an adjuvant in improving glycaemic control and residual pancreatic beta-cell function.
Blinding efforts:
Double blinded. Allocation concealment was done using pre-printed randomization sequences kept in opaque sealed envelopes. The principal investigator and lab personnel were blinded to the group allocation.
Study Location:
Southern India. JIPMER, a tertiary care teaching hospital,
Source(s) of Funding:
University/Hospital
Please specify names of funders:
JIPMER (Jawaharlal Institute of Postgraduate Medical Education & Research)