CRDA: Lipid Outcomes (2023)

Author and Year:
Ryan M, Itsiopoulos C, Thodis T, et al. 2013
PubMed ID:
Article Title:
The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease.
Ryan M, Itsiopoulos C, Thodis T, Ward G, Trost N, Hofferberth S, O'Dea K, Desmond P, Johnson N, Wilson A
Journal of Hepatology
Year of publication:
Page numbers:
Study Design:
Randomized Crossover Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
Evidence of steatosis both on ultra-sonography and histology (>grade 1 steatosis [33% steatotic hepatocytes]) Presence of MetSy, as defined by the presence of at least three clinical features using National Cholesterol Education Program Adult treatment Panel III (NCEPATP III) criteria.
Exclusion Criteria:
Type 1 or 2 diabetes
Research Purpose:
We hypothesized that in individuals with NAFLD an MD interventionwould improve insulin sensitivity and reduce steatosis to a greater extent than the currently recommended diet.
Blinding efforts:
Study Location:
Melbourne, Australia
Source(s) of Funding:
University/Hospital, Professional organization
Please specify names of funders:
National Health and Medical Research Council (NHMRC) Neil Hamilton Fairley Fellowship Early Career Researcher Grant from the University of Melbourne