Marin-Alejandre B, Cantero I, et al. 2021

33550706

Effects of two personalized dietary strategies during a 2-year intervention in subjects with nonalcoholic fatty liver disease: A randomized trial.

Marin-Alejandre B, Cantero I, Perez-Diaz-Del-Campo N, Monreal J, Elorz M,Herrero J, Benito-Boillos A, Quiroga J, Martinez-Echeverria A, Uriz-Otano J, Huarte-Muniesa M, Tur J, Martinez J, Abete I, Zulet M

Liver International

2021

41

7

1532-1544

Randomized Controlled Trial

Low risk

Overweight or obese (BMI >/= 27.5 kg/m2 to < 40 kg/m2); 40-80 years old; hepatic steatosis confirmed by abdominal ultrasonography

Presence of known liver disease other than NAFLD; >/= 3 kg of body weight loss in the last 3 months; excessive alcohol consumption (>21 and >14 units of alcohol per week for men and women, respectively); endocrine disorders (hyperthyroidism or uncontrolled hypothyroidism); pharmacological treatment with immunosuppressants, cytotoxic agents, systemic corticosteroids (or other drugs that could potentially cause hepatic steatosis or altering liver tests); active autoimmune diseases or requiring pharmacological treatment; use of weight modifiers; severe psychiatric disorders; lack of autonomy or an inability to follow the diet; difficulties in following the scheduled visits.

To evaluate the long term effects of two personalized energy-restricted dietary strategies on weight loss, anthropometric measurements, biochemical determinations and hepatic status within a 2-year follow-up in overweight or obese subjects with NAFLD.

Spain

Government, Foundation

Health Department of the Government of Navarra, CIBERobn (Physiopathology of Obesity and Nutrition), Fundació La Marató de TV3, Principal author was supported by fellowships from Consejo Nacional de Ciencia y Tecnología (CONACYT) y el Estado de Michoacán