CRDA: Lipid Outcomes (2023)

Author and Year:
Marin-Alejandre B, Cantero I, et al. 2021
PubMed ID:
Article Title:
Effects of two personalized dietary strategies during a 2-year intervention in subjects with nonalcoholic fatty liver disease: A randomized trial.
Marin-Alejandre B, Cantero I, Perez-Diaz-Del-Campo N, Monreal J, Elorz M,Herrero J, Benito-Boillos A, Quiroga J, Martinez-Echeverria A, Uriz-Otano J, Huarte-Muniesa M, Tur J, Martinez J, Abete I, Zulet M
Liver International
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Low risk
Inclusion Criteria:
Overweight or obese (BMI >/= 27.5 kg/m2 to < 40 kg/m2); 40-80 years old; hepatic steatosis confirmed by abdominal ultrasonography
Exclusion Criteria:
Presence of known liver disease other than NAFLD; >/= 3 kg of body weight loss in the last 3 months; excessive alcohol consumption (>21 and >14 units of alcohol per week for men and women, respectively); endocrine disorders (hyperthyroidism or uncontrolled hypothyroidism); pharmacological treatment with immunosuppressants, cytotoxic agents, systemic corticosteroids (or other drugs that could potentially cause hepatic steatosis or altering liver tests); active autoimmune diseases or requiring pharmacological treatment; use of weight modifiers; severe psychiatric disorders; lack of autonomy or an inability to follow the diet; difficulties in following the scheduled visits.
Research Purpose:
To evaluate the long term effects of two personalized energy-restricted dietary strategies on weight loss, anthropometric measurements, biochemical determinations and hepatic status within a 2-year follow-up in overweight or obese subjects with NAFLD.
Blinding efforts:
Study Location:
Source(s) of Funding:
Government, Foundation
Please specify names of funders:
Health Department of the Government of Navarra, CIBERobn (Physiopathology of Obesity and Nutrition), Fundació La Marató de TV3, Principal author was supported by fellowships from Consejo Nacional de Ciencia y Tecnología (CONACYT) y el Estado de Michoacán