CRDA: Inflammatory Marker Outcomes (2023)

Author and Year:
Falkenhain K, Locke S, et al. 2021
PubMed ID:
Article Title:
Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial.
Falkenhain K, Locke S, Lowe D, Reitsma N, Lee T, Singer J, Weiss E, Little J
Obesity (Silver Spring, Md.)
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Inclusion Criteria:
Aged 18-64 years; living in the state of California; BMI 27-43 kg/m2; must speak, read, and comprehend English; must have a valid email address and phone number; willingness to follow an evidence-based very low carbohydrate diet or calorie-restricted diet that has been demonstrated for weight loss; must have a kitchen and be willing to cook; willingness to reduce (net) carbohydrate intake to less than 30 g/day; willingness to restrict intake of added sugar, bread, grain, rice, pasta, sweets, most fruits, pastries, and other carbohydrates; willingness to comply with a strict diet for 12 months; interest in losing weight
Exclusion Criteria:
HIV or immunocompromised; current or past cancer diagnosis; pregnant, breastfeeding, or planned pregnancy in next 12 months; beginning or ending hormonal contraception in next 12 months; current diagnosis of diabetes; history of heart attack or stent; currently taking glucose-lowering drugs, statins, or oral steroids; history of gastric bypass surgery or any other weight-loss surgery; history of anorexia or bulimia; history of mental illness; current smoker or smoked cigarettes within past 12 months; currently eating fewer than 50g carbohydrates per day; currently following a ketogenic diet or have strictly adhered to a ketogenic diet for greater than 3 weeks in the past 6 months; lost or gained more than 5% body weight in past 6 months; currently using Weight Watchers or have strictly adhered to the WW app for greater than 3 weeks in the past 6 months
Research Purpose:
To test the efficacy of the Keyto diet app and breath acetone biofeedback device compared with the WW diet app (low fat)
Blinding efforts:
Not applicable
Study Location:
California (virtual participation)
Source(s) of Funding:
Government, Not-for-profit
Please specify names of funders:
Canadian Institutes of Health Research (MSH- 141980), Michael Smith Foundation for Health Research (MSFHR 16890), and Mitacs (IT15608).