HTN: Medical Nutrition Therapy (2022-24)
Author and Year:
Hjelstuen A, Anderssen S, Holme I, et al. 2007
PubMed ID:
Article Title:
Effect of lifestyle and/or statin treatment on soluble markers of atherosclerosis in hypertensives.
Authors:
Hjelstuen A, Anderssen S, Holme I, Seljeflot I, Klemsdal T
Journal:
Scandinavian Cardiovascular Journal
Year of publication:
2007
Volume:
41
Issue:
5
Page numbers:
313-320
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
The participants were all men between 40 and 75 years of age on drug treatment for essential hypertension. Other inclusion criteria were overweight, defined as BMI between 25 and 35 kg/m2, and a sedentary lifestyle, defined as less than 1 hour of regular exercise a week.
Exclusion Criteria:
Individuals with clinical manifestation of atherosclerotic disease, such as previous or present cerebrovascular or coronary heart disease, were excluded. Other exclusion criteria were treatment with lipid lowering medication, insulin dependent diabetes mellitus, total cholesterol (TC) >8.0 mmol/l or s-triglycerides (TG) >4.5 mmol/l.
Research Purpose:
To investigate the independent and combined effects of lifestyle changes and statin treatment on soluble markers of atherosclerotic activity.
Blinding efforts:
See Risk of Bias.
Study Location:
Norway
Source(s) of Funding:
Industry, University/Hospital
Please specify names of funders:
Ulleval University Hospital, Norwegian School of Sports Sciences, and Novartis Pharma AG.