Shah B, Newman J, Woolf K, et al. 2018

30571591

Anti-Inflammatory Effects of a Vegan Diet Versus the American Heart Association-Recommended Diet in Coronary Artery Disease Trial.

Shah B, Newman J, Woolf K, Ganguzza L, Guo Y, Allen N, Zhong J, Fisher E, Slater J

Journal of the American Heart Association

2018

7

23

e011367

Randomized Controlled Trial

Low risk

History of angiographically defined CAD (at least 50% lesion in an artery with at least 2-mm caliber) underwent 1:1 randomization to either a vegan diet or the AHA-recommended diet.

(1) history of an eating disorder; (2) already on a vegetarian or vegan diet; (3) use of steroids or nonsteroidal anti-inflammatory medications other than aspirin; (4) history of a myocardial infarction or coronary artery bypass graft surgery within the preceding 3 months; (5) presence of infection within the preceding 3 months; and (6) have a planned staged coronary revascularization or other surgical procedure during study period. Potential participants were also excluded if they had a score of >4 on any of the motivational items or if the relative autonomy index (defined as average of answers for the 6 autonomous items—average of answers for the 6 controlled items) was ?0 on a treatment self-regulation questionnaire

The aim of this study was to determine the effects of a vegan versus AHA-recommended diet on hsCRP, as well as other markers of inflammation, glucometabolic markers, and lipid profiles in patients with established CAD on guideline directed medical therapy.

United States

Not-for-profit

Purjes Foundation