VN: Cardiovascular Disease Risk Factors (2024)

Author and Year:
KahleovaH, Petersen K, Shulman G, et al. 2020
PubMed ID:
Article Title:
Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults: A Randomized Clinical Trial.
Kahleova H, Petersen K, Shulman G, Alwarith J, Rembert E, Tura A, Hill M, Holubkov R, Barnard N
JAMA Network Open
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Low risk
Inclusion Criteria:
Adults aged 25 to 75 years with a body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) of 28 to 40 were enrolled.
Exclusion Criteria:
Exclusion criteria were diabetes, smoking, alcohol or drug use, pregnancy or lactation, and current use of a vegan diet. The additional exclusion criteria for the subset of participants undergoing the proton magnetic resonance spectroscopy were the presence of any metal implant, claustrophobia, BMI higher than 38, and waist circumference of more than 102 cm
Research Purpose:
The aim of this study was to measure the effects of a low-fat vegan diet on body weight, insulin resistance, postprandial metabolism, and intramyocellular and hepatocellular lipid levels in overweight adults.
Blinding efforts:
Participants were not blinded to their group assignment. The outcome assessors were blinded to group assignment. The statisticians were blinded to the interventions and group assignment.
Study Location:
Washington DC
Source(s) of Funding:
Government, Not-for-profit
Please specify names of funders:
Physicians Committee for Responsible Medicine, NIH