Mahon A, Flynn M, Stewart L, et al. 2007

17536130

Protein intake during energy restriction: effects on body composition and markers of metabolic and cardiovascular health in postmenopausal women.

Mahon A, Flynn M, Stewart L, McFarlin B, Iglay H, Mattes R, Lyle R, Considine R, Campbell W

Journal of the American College of Nutrition

2007

26

2

182-189

Randomized Controlled Trial

Some concerns

Postmenopausal women not meeting exclusion criteria.

The exclusion criteria were the following: male, age <50 or > 80 years, BMI <25 and >34 kg/m2 at the time of screening, a smoker, and clinically abnormal kidney, liver, or heart function. Subjects could not be individuals with diabetes or unstable thyroid disease, in abnormal protein or hematological status, nor receiving insulin replacement therapy or anti-inflammatory steroid medications. Women <2 years postmenopausal.

The primary purpose of the study was to compare the short-term effects of two energy restriction (ER), moderately high protein (MHP) diets that differed in protein source (either beef or chicken as the primary protein source, both 26%of energy) vs. a lacto-ovo vegetarian lower protein (LP) diet that differed in protein quantity (16% of energy) on changes in body mass and body composition. Secondary aims included analyses of lipoprotein-lipid profile, CRP, glucose, insulin, leptin and adiponectin concentrations in overweight and mildly obese postmenopausal women.

Not reported

Lafayette, IN, USA

Industry, Government, Industry, University/Hospital

Cattlemen's Beef Board and the National Cattlemen's Beef Association (Centennial, CO), Agriculture Research Program & Lynn Fellowships at Purdue University, and NIH R29 AG13409