VN: Cardiovascular Disease Risk Factors (2024)

Author and Year:
Mahon A, Flynn M, Stewart L, et al. 2007
PubMed ID:
Article Title:
Protein intake during energy restriction: effects on body composition and markers of metabolic and cardiovascular health in postmenopausal women.
Mahon A, Flynn M, Stewart L, McFarlin B, Iglay H, Mattes R, Lyle R, Considine R, Campbell W
Journal of the American College of Nutrition
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
Postmenopausal women not meeting exclusion criteria.
Exclusion Criteria:
The exclusion criteria were the following: male, age <50 or > 80 years, BMI <25 and >34 kg/m2 at the time of screening, a smoker, and clinically abnormal kidney, liver, or heart function. Subjects could not be individuals with diabetes or unstable thyroid disease, in abnormal protein or hematological status, nor receiving insulin replacement therapy or anti-inflammatory steroid medications. Women <2 years postmenopausal.
Research Purpose:
The primary purpose of the study was to compare the short-term effects of two energy restriction (ER), moderately high protein (MHP) diets that differed in protein source (either beef or chicken as the primary protein source, both 26%of energy) vs. a lacto-ovo vegetarian lower protein (LP) diet that differed in protein quantity (16% of energy) on changes in body mass and body composition. Secondary aims included analyses of lipoprotein-lipid profile, CRP, glucose, insulin, leptin and adiponectin concentrations in overweight and mildly obese postmenopausal women.
Blinding efforts:
Not reported
Study Location:
Lafayette, IN, USA
Source(s) of Funding:
Industry, Government, Industry, University/Hospital
Please specify names of funders:
Cattlemen's Beef Board and the National Cattlemen's Beef Association (Centennial, CO), Agriculture Research Program & Lynn Fellowships at Purdue University, and NIH R29 AG13409