MNT: Interventions for Adults with Malnutrition (2023-25)
Author and Year:
Lyu J, Shi A, Li T, et al. 2022
PubMed ID:
Article Title:
Effects of Enteral Nutrition on Patients With Oesophageal Carcinoma Treated With Concurrent Chemoradiotherapy: A Prospective, Multicentre, Randomised, Controlled Study.
Authors:
Lyu J, Shi A, Li T, Li J, Zhao R, Zhu S, Wang J, Xing L, Yang D, Xie C, Shen L, Zhang H, Zhu G, Wang J, Pan W, Li F, Lang J, Shi H
Journal:
Frontiers in Oncology
Year of publication:
2022
Volume:
12
Issue:
Page numbers:
839516
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
(1) histologically confirmed, stage II-III oesophageal carcinoma; (2) adequate digestive and absorption functions; (3) 18 years /=2 points; (5) Karnofsky performance status (KPS) scores >/= 70 points; (6) adequate haematological, renal, hepatic and pulmonary functions (defined as, absolute neutrophil count >/= 1500 cells/mm, a platelet count >/= 100000 cells/mm3, haemoglobin levels >/= 9.0 g/dL, bilirubin levels
Exclusion Criteria:
(1) the intestinal functions severely impaired or patients intolerant to enteral nutrition; (2) incapable of oral feeding and insertion of nutrition tube or unwilling to accept the insertion of nutrition tube; (3) no malnutrition or nutritional risk; (4) severe malnutrition (weight loss > 10% or serum albumin [ALB] < 30 g/L or BMI < 18.5 kg/m2 or haemoglobin < 90 g/L) before the treatment; (5) serious heart, lung, liver and kidney diseases; (6) mental disease or severe cognitive disorder.
Research Purpose:
To assess the effects of enteral nutrition on the nutritional status, treatment toxicities and survival in the oesophageal carcinoma patients treated with concurrent chemoradiotherapy (CCRT).
Blinding efforts:
Study Location:
China
Source(s) of Funding:
Not-for-profit
Please specify names of funders:
This study was funded by the Wu Jieping Medical Foundation (320.6750.17237).