Chronic Kidney Disease

CKD: Thiamin with Vitamin B6 (2018)

• Intervention
  What is the effect of supplementation of thiamin with vitamin B6 on thiamin levels in adults with CKD 1-5D and post-transplant?

  • Conclusion

    Results regarding the effect of thiamin supplementation were limited and unclear.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What is the effect of supplementation of thiamin with vitamin B6 on thiamin levels in adults with CKD 1-5D and post-transplant?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Frank T, Czeche K, Bitsch R, Stein G. Assessment of thiamin status in chronic renal failure patients, transplant recipients and hemodialysis patients receiving a multivitamin supplementation. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2000; 70:159-66
  • Search Plan and Results: CKD: Micronutrients: Thiamin with B6 (2018)
     
  What is the effect of supplementation of thiamin with vitamin B6 on inflammatory markers in adults with CKD 1-5D and post-transplant?

  • Conclusion

    There was no effect of oral thiamin and pyridoxine supplementation on inflammatory marker C-reactive protein (CRP) or cytokine IL-6 levels, but evidence was limited.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What is the effect of supplementation of thiamin with vitamin B6 on inflammatory markers in adults with CKD 1-5D and post-transplant?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Nascimento M, Suliman M, Murayama Y, Nihi M, Hayashi S, Stenvinkel P, Riella M, Lindholm B. Effect of high-dose thiamine and pyridoxine on advanced glycation end products and other oxidative stress markers in hemodialysis patients: a randomized placebo-controlled study. Journal of Renal Nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2006; 16:119-24
  • Search Plan and Results: CKD: Micronutrients: Thiamin with B6 (2018)