CKD: Vitamin E (2018)

Intervention
What is the effect of vitamin E supplementation on all-cause mortality in adults with CKD 1-5D and post-transplant?
- Conclusion
  Vitamin E supplementation did not affect mortality.
- Grade: I
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin E supplementation on all-cause mortality in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrient: Vitamin E (2018)
What is the effect of vitamin E supplementation on CVD outcome in adults with CKD 1-5D and post-transplant?
- Conclusion
  Vitamin E supplementation did not affect cardiovascular disease outcomes.
- Grade: II
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin E supplementation on CVD outcome in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrient: Vitamin E (2018)
What is the effect of vitamin E supplementation on lipid profile in adults with CKD 1-5D and post-transplant?
- Conclusion
  Vitamin E supplementation of 110-200 mg per day may increase high-density lipoprotein (HDL) levels, but there was no other effect on lipid profile.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin E supplementation on lipid profile in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrient: Vitamin E (2018)
What is the effect of vitamin E supplementation on vitamin E levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  Vitamin E supplementation alone did not affect vitamin E levels.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin E supplementation on vitamin E levels in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrient: Vitamin E (2018)
What is the effect of vitamin E supplementation on BMI in adults with CKD 1-5D and post-transplant?
- Conclusion
  There was no effect of vitamin E supplementation, with or without alpha-lipoic acid, on BMI.
- Grade: II
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin E supplementation on BMI in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrient: Vitamin E (2018)
What is the effect of vitamin E supplementation on CRP levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  There was no effect of vitamin E supplementation, with or without alpha-lipoic acid, on C-reactive protein (CRP) levels.
- Grade: II
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin E supplementation on CRP levels in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrient: Vitamin E (2018)
What is the effect of vitamin E supplementation on IL-6 levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  There was no effect of vitamin E supplementation alone or with a-lipoic acid on IL-6 levels compared to placebo groups.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin E supplementation on IL-6 levels in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrient: Vitamin E (2018)
What is the effect of vitamin E supplementation on SGA score in adults with CKD 1-5D and post-transplant?
- Conclusion
  Vitamin E supplementation alone (400 IU per day for two months) or with a-lipoic acid did not affect subjective global assessment (SGA) score.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin E supplementation on SGA score in adults with CKD 1-5D and post-transplant?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Ahmadi A, Mazooji N, Roozbeh J, Mazloom Z, Hasanzade J. Effect of alpha-lipoic acid and vitamin E supplementation on oxidative stress, inflammation, and malnutrition in hemodialysis patients. Iranian Journal of Kidney Diseases 2013; 7:461-7
- Search Plan and Results: CKD: Micronutrient: Vitamin E (2018)
What is the effect of vitamin E supplementation on albumin levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  Vitamin E (90 mg per day for 16 weeks) supplementation had no effect on albumin levels, but evidence was limited.
- Grade: II
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin E supplementation on albumin levels in adults with CKD 1-5D and post-transplant?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Daud Z, Tubie B, Sheyman M, Osia R, Adams J, Tubie S, Khosla P. Vitamin E tocotrienol supplementation improves lipid profiles in chronic hemodialysis patients. Vascular Health and Risk Management 2013; 9:747-61
- Search Plan and Results: CKD: Micronutrient: Vitamin E (2018)