CKD: Vitamin D (2018)

Intervention
What is the effect of vitamin D supplementation on mortality in adults with CKD 1-5D and post-transplant?
- Conclusion
  Vitamin D supplementation did not affect mortality rates, but studies were too few and too underpowered to draw conclusions.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on mortality in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on quality of life in adults with CKD 1-5D and post-transplant?
- Conclusion
  Cholecalciferol supplementation did not affect quality of life (QoL), but evidence was too limited to draw conclusions.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on quality of life in adults with CKD 1-5D and post-transplant?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Hewitt N, O'Connor A, O'Shaughnessy D, Elder G. Effects of cholecalciferol on functional, biochemical, vascular, and quality of life outcomes in hemodialysis patients. Clinical Journal of the American Society of Nephrology 2013; 8:1143-9
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on hospitalizations in adults with CKD 1-5D and post-transplant?
- Conclusion
  Vitamin D supplementation did not affect hospitalization rates.
- Grade: II
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on hospitalizations in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on lipid profile in adults with CKD 1-5D and post-transplant?
- Conclusion
  Cholecalciferol supplementation had no effect on lipid profile.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on lipid profile in adults with CKD 1-5D and post-transplant?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Khajehdehi P. Effect of vitamins on the lipid profile of patients on regular hemodialysis. Scandinavian Journal of Urology and Nephrology 2000; 34:62-6
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on blood glucose parameters in adults with CKD 1-5D and post-transplant?
- Conclusion
  Cholecalciferol supplementation regimen did not affect blood glucose parameters in pre-dialysis patients with diabetes mellitus.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on blood glucose parameters in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on arterial calcification in adults with CKD 1-5D and post-transplant?
- Conclusion
  There was no long-term effect of cholecalciferol supplementation on arterial calcification, but studies were too few and sample sizes too low to draw conclusions.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on arterial calcification in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on blood pressure in adults with CKD 1-5D and post-transplant?
- Conclusion
  Neither ergocalciferol nor cholecalciferol supplementation affected blood pressure.
- Grade: II
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on blood pressure in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on eGFR in adults with CKD 1-5D and post-transplant?
- Conclusion
  There was no effect of cholecalciferol supplementation on eGFR, but evidence was too limited to draw any conclusions.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on eGFR in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on creatinine levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  There was no effect of cholecalciferol supplementation or dosing regimen on creatinine levels, but studies were too under-powered to draw any conclusions.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on creatinine levels in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on calcium and phosphorus levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  There was no effect of vitamin D supplementation on calcium levels. Neither ergocalciferol nor cholecalciferol supplementation affected phosphorus levels.
- Grade: II
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on calcium and phosphorus levels in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on magnesium levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  There was no effect of cholecalciferol supplementation regimen on magnesium levels, but evidence was limited.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on magnesium levels in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on sodium levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  There was no effect of cholecalciferol supplementation on sodium levels, but evidence was limited.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on sodium levels in adults with CKD 1-5D and post-transplant?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Khajehdehi P. Effect of vitamins on the lipid profile of patients on regular hemodialysis. Scandinavian Journal of Urology and Nephrology 2000; 34:62-6
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on vitamin D status and vitamin 25(OH)D levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  Both ergocalciferol and cholecalciferol supplementation increase vitamin 25(OH)D levels as well as the proportion of participants with vitamin D sufficiency.
- Grade: I
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on vitamin D status and vitamin 25(OH)D levels in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on inflammatory marker levels in adults with CKD 1-5D and post-transplant?
- Conclusion
  Vitamin D given in the form of ergocalciferol was associated with a decrease in serum C-reactive protein (CRP) levels in hemodialysis patients, but a causal relationship was not demonstrated. CRP levels were not affected by cholecalciferol supplementation of 20,000-50,000 IU per week, but decreased with 50,000 IU cholecalciferol 2 times per week.Cholecalciferol supplementation did not affect IL-6 or tumour necrosis factor alpha (NF-a) levels.
- Grade: II
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on inflammatory marker levels in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)
What is the effect of vitamin D supplementation on nutritional status indicators in adults with CKD 1-5D and post-transplant?
- Conclusion
  Cholecalciferol supplementation did not affect albumin levels.
- Grade: III
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: What is the effect of vitamin D supplementation on nutritional status in adults with CKD 1-5D and post-transplant?
- Search Plan and Results: CKD: Micronutrients: Vitamin D (2018)