CD: Supplements (2021)

Intervention
In patients with celiac disease, what are the effects of supplements (e.g., calcium, iron, B vitamins, zinc, copper, multivitamin), compared to a control, on anthropometrics?
- Conclusion
  In zinc-deficient children with celiac disease, there was no effect on weight gain between the group who received a zinc supplement in addition to a gluten-free diet and those who just received a gluten-free diet. (Moderate)
- Grade: Moderate (B)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In patients with celiac disease, what are the effects of supplements (e.g., calcium, iron, B vitamins, zinc, copper, multivitamin), compared to a control, on anthropometrics?
- Search Plan and Results: CD: Supplements 2020
In patients with celiac disease, what are the effects of supplements (e.g., calcium, iron, B vitamins, zinc, copper, multivitamin), compared to a control, on nutrition-related laboratory measures?
- Conclusion
  In healthy patients with celiac disease, there was a significant increase in plasma hemoglobin, ferritin, vitamin B6, folate, vitamin B12 and a reduction in homocysteine and occurrence of zinc deficiency among celiac patients who received a supplement in comparison to those who received a placebo or did not take a supplement. There was no difference in serum L-carnitine levels between celiac patients who received a supplement and those who received a placebo.
  
  [Grade III or Very Low.]
- Grade: Very Low (D)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In patients with celiac disease, what are the effects of supplements (e.g., calcium, iron, B vitamins, zinc, copper, multivitamin), compared to a control, on nutrition-related laboratory measures ?
- Search Plan and Results: CD: Supplements 2020
In patients with celiac disease, what are the effects of supplements (e.g., calcium, iron, B vitamins, zinc, copper, multivitamin), compared to a control, on quality of life?
- Conclusion
  In healthy adults with celiac disease, there was a greater reduction in self-reported fatigue among participants who received supplements in comparison to participants who received a placebo, but there was no significant difference between groups in measures of other indicators of quality of life.
  
  [Grade III or Very Low]
- Grade: Very Low (D)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In patients with celiac disease, what are the effects of supplements (e.g., calcium, iron, B vitamins, zinc, copper, multivitamin), compared to a control, on quality of life?
- Search Plan and Results: CD: Supplements 2020