CF: Infant Feeding
Author and Year:
Leung D, Heltshe S, et al. 2017
PubMed ID:
Article Title:
Effects of Diagnosis by Newborn Screening for Cystic Fibrosis on Weight and Length in the First Year of Life.
Authors:
Leung D, Heltshe S, Borowitz D, Gelfond D, Kloster M, Heubi J, Stalvey M, Ramsey B
Journal:
JAMA Pediatrics
Year of publication:
2017
Volume:
171
Issue:
6
Page numbers:
546-554
Study Design:
Prospective Cohort Study
Risk of Bias Assessment Rating:
Neutral
Inclusion Criteria:
Infants younger than 3.5 months were enrolled if they had a sweat chloride level of at least 60 mEq/L (to convert to millimoles per liter, multiply by 1) by using a quantitative pilocarpine iontophoresis test or 2 well-characterized CF transmembrane conductance regulator gene (CFTR [NCBI Entrez Gene 1080]) mutations.
Exclusion Criteria:
Infants with a gestational age of less than 35 weeks, with a birth weight of less than 2.5 kg, unable to take full oral feeds, or with any serious condition other than pancreatic insufficiency (PI) contributing to malabsorption or interfering with normal growth were excluded.
Research Purpose:
To examine the current state of weight gain and linear growth in the first year of life, framed within the context of historic growth patterns in CF
Blinding efforts:
Not reported
Study Location:
United States
Source(s) of Funding:
Not-for-profit
Please specify names of funders:
This study was supported by grants BONUS11KO from Cystic Fiborosis Foundation Therapeutics; grants R01DK095738, P30DK089507, UL1TR000423, and P30 DK072482 from the NIH; and grant LEUNG14GE0 from the CFF.
Trial Name:
BONUS