CD: Prebiotics/Probiotics (2021)

CD: Prebiotics/Probiotics (2021)

• Intervention
  In patients with celiac disease, what are the effects of prebiotics or probiotics, compared to a control, on anthropometrics?

  • Conclusion

    The effects of prebiotics or probiotics on anthropometric outcomes were inconclusive. In children, there is conflicting evidence on the role probiotics may play in impacting height and there is no evidence to suggest that prebiotics or probiotics impact weight or other anthropometric indicators (Grade III or Low).

  • Grade: Low (C)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of prebiotics or probiotics, compared to a control, on anthropometrics?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Drabinska N, Jarocka-Cyrta E, Zlotkowska D, Abramowicz P, Krupa-Kozak U. Daily oligofructose-enriched inulin intake impacts bone turnover markers but not the cytokine profile in pediatric patients with celiac disease on a gluten-free diet: Results of a randomised, placebo-controlled pilot study. Bone 2019; 122:184-192
      • Olivares M, Castillejo G, Varea V, Sanz Y. Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease. British Journal of Nutrition 2014; 112:30-40
  • Search Plan and Results: CD: Prebiotics/Probiotics 2020
     
  In patients with celiac disease, what are the effects of prebiotics or probiotics, compared to a control, on bone health?

  • Conclusion

    The effect of prebiotics or probiotics on indicators of bone metabolism among patients with celiac disease is inconclusive. Limited evidence suggests that prebiotics or probiotics may impact some specific bone metabolism biomarkers, such as pyridinoline, but not others, including plasma osteocalcin (Grade III or Low).

  • Grade: Low (C)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of prebiotics or probiotics, compared to a control, on bone health?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Drabinska N, Jarocka-Cyrta E, Zlotkowska D, Abramowicz P, Krupa-Kozak U. Daily oligofructose-enriched inulin intake impacts bone turnover markers but not the cytokine profile in pediatric patients with celiac disease on a gluten-free diet: Results of a randomised, placebo-controlled pilot study. Bone 2019; 122:184-192
  • Search Plan and Results: CD: Prebiotics/Probiotics 2020
     
  In patients with celiac disease, what are the effects of prebiotics or probiotics, compared to a control, on nutrition-related laboratory measures?

  • Conclusion

    The effects of prebiotics or probiotics on nutrition-related laboratory measures were unclear. Limited evidence suggests that supplementation with probiotics may improve micronutrient status indicators, such as plasma concentrations of vitamins E and D (Grade II or Moderate).

  • Grade: Moderate (B)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of prebiotics or probiotics, compared to a control, on nutrition-related laboratory measures?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Drabinska N, Krupa-Kozak U, Abramowicz P, Jarocka-Cyrta E. Beneficial Effect of Oligofructose-Enriched Inulin on Vitamin D and E Status in Children with Celiac Disease on a Long-Term Gluten-Free Diet: A Preliminary Randomized, Placebo-Controlled Nutritional Intervention Study. Nutrients 2018; 10:1768
      • Drabinska N, Krupa-Kozak U, Ciska E, Jarocka-Cyrta E. Plasma profile and urine excretion of amino acids in children with celiac disease on gluten-free diet after oligofructose-enriched inulin intervention: results of a randomised placebo-controlled pilot study. Amino Acids 2018; 50:1451-1460
      • Ferus K, Drabinska N, Krupa-Kozak U, Jarocka-Cyrta E. A Randomized, Placebo-Controlled, Pilot Clinical Trial to Evaluate the Effect of Supplementation withPrebiotic Synergy 1 on Iron Homeostasis in Children and Adolescents with Celiac Disease Treated with a Gluten-Free Diet. Nutrients 2018; 10:1818
  • Search Plan and Results: CD: Prebiotics/Probiotics 2020
     
  In patients with celiac disease, what are the effects of prebiotics or probiotics, compared to a control, on gastrointestinal health and gastrointestinal symptoms?

  • Conclusion

    The effect of prebiotics or probiotics on indicators of gastrointestinal health and gastrointestinal symptoms among patients with celiac disease is unclear. There is limited and inconsistent evidence on the role prebiotics or probiotics play in improving gastrointestinal symptoms. All five studies that explored microbiota changes noted some changes between Probiotic and Placebo Groups, but the microbiota changes were inconsistent between studies (Grade III or Very Low).

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of prebiotics or probiotics, compared to a control, on gastrointestinal health and gastrointestinal symptoms?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Drabinska N, Krupa-Kozak U, Ciska E, Jarocka-Cyrta E. Plasma profile and urine excretion of amino acids in children with celiac disease on gluten-free diet after oligofructose-enriched inulin intervention: results of a randomised placebo-controlled pilot study. Amino Acids 2018; 50:1451-1460
      • Francavilla R, Piccolo M, Francavilla A, Polimeno L, Semeraro F, Cristofori F, Castellaneta S, Barone M, Indrio F, Gobbetti M, De Angelis M. Clinical and Microbiological Effect of a Multispecies Probiotic Supplementation in Celiac Patients With Persistent IBS-type Symptoms: A Randomized, Double-Blind, Placebo-controlled, Multicenter Trial. Journal of Clinical Gastroenterology 2019; 53:e117-e125
      • Harnett J, Myers S, Rolfe M. Probiotics and the Microbiome in Celiac Disease: A Randomised Controlled Trial. Evidence-based Complementary and Alternative medicine 2016; 2016:9048574
      • Olivares M, Castillejo G, Varea V, Sanz Y. Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease. British Journal of Nutrition 2014; 112:30-40
      • Pinto-Sánchez M, Smecuol E, Temprano M, Sugai E, González A, Moreno M, Huang X, Bercik P, Cabanne A, Vázquez H, Niveloni S, Mazure R, Mauriño E, Verdú E, Bai J. Bifidobacterium infantis NLS Super Strain Reduces the Expression of a-Defensin-5, a Marker of Innate Immunity, in the Mucosa of Active Celiac Disease Patients. Journal of Clinical Gastroenterology 2017; 51:814-817
      • Quagliariello A, Aloisio I, Cionci NB, Luiselli D, D'Auria G, Martinez-Priego L, Perez-Villarroya D, Langerholc T, Primec M, Micetic-Turk D, Di Gioia D.. Effect of Bifidobacterium breve on the intestinal microbiota of coeliac children on a gluten free diet: a pilot study. Nutrients 2016; 8:660
      • Smecuol E, Hwang H, Sugai E, Corso L, Cherñavsky A, Bellavite F, González A, Vodánovich F, Moreno M, Vázquez H, Lozano G, Niveloni S, Mazure R, Meddings J, Mauriño E, Bai J. Exploratory, randomized, double-blind, placebo-controlled study on the effects of Bifidobacterium infantis natren life start strain super strain in active celiac disease. Journal of Clinical Gastroenterology 2013; 47:139-147
  • Search Plan and Results: CD: Prebiotics/Probiotics 2020
     
  In patients with celiac disease, what are the effects of prebiotics or probiotics, compared to a control, on celiac disease-related antibodies, inflammatory and immunological indicators?

  • Conclusion

    The effect of prebiotics or probiotics on celiac disease-related antibodies, inflammatory and immunological indicators is inconclusive. Limited evidence suggests that prebiotics or probiotics may impact some immunological indicators, such as CD3+ T-cells, but not others, including IgA tTG, IgA DGP and IL-6 (Grade III or Very Low).

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of prebiotics or probiotics, compared to a control, on celiac disease-related antibodies, inflammatory and immunological indicators?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Drabinska N, Jarocka-Cyrta E, Zlotkowska D, Abramowicz P, Krupa-Kozak U. Daily oligofructose-enriched inulin intake impacts bone turnover markers but not the cytokine profile in pediatric patients with celiac disease on a gluten-free diet: Results of a randomised, placebo-controlled pilot study. Bone 2019; 122:184-192
      • Ferus K, Drabinska N, Krupa-Kozak U, Jarocka-Cyrta E. A Randomized, Placebo-Controlled, Pilot Clinical Trial to Evaluate the Effect of Supplementation withPrebiotic Synergy 1 on Iron Homeostasis in Children and Adolescents with Celiac Disease Treated with a Gluten-Free Diet. Nutrients 2018; 10:1818
      • Olivares M, Castillejo G, Varea V, Sanz Y. Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease. British Journal of Nutrition 2014; 112:30-40
      • Smecuol E, Hwang H, Sugai E, Corso L, Cherñavsky A, Bellavite F, González A, Vodánovich F, Moreno M, Vázquez H, Lozano G, Niveloni S, Mazure R, Meddings J, Mauriño E, Bai J. Exploratory, randomized, double-blind, placebo-controlled study on the effects of Bifidobacterium infantis natren life start strain super strain in active celiac disease. Journal of Clinical Gastroenterology 2013; 47:139-147
  • Search Plan and Results: CD: Prebiotics/Probiotics 2020
     
  In patients with celiac disease, what are the effects of prebiotics or probiotics, compared to a control, on quality of life?

  • Conclusion

    There is no evidence to suggest that prebiotics or probiotics impact quality of life indicators among patients with celiac disease (Grade III or Low).

  • Grade: Low (C)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of prebiotics or probiotics, compared to a control, on quality of life?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Francavilla R, Piccolo M, Francavilla A, Polimeno L, Semeraro F, Cristofori F, Castellaneta S, Barone M, Indrio F, Gobbetti M, De Angelis M. Clinical and Microbiological Effect of a Multispecies Probiotic Supplementation in Celiac Patients With Persistent IBS-type Symptoms: A Randomized, Double-Blind, Placebo-controlled, Multicenter Trial. Journal of Clinical Gastroenterology 2019; 53:e117-e125
  • Search Plan and Results: CD: Prebiotics/Probiotics 2020