CRDA: Inflammatory Marker Outcomes (2023)

CRDA: Inflammatory Marker Outcomes (2023)

• Intervention
  In adults with type 2 diabetes, what is the effect of carbohydrate (CHO) restriction compared to higher CHO diets on C-reactive protein?

  • Conclusion

    Evidence suggests that intake of a moderate-carbohydrate (CHO) diet compared to a higher CHO intake may have little or no effect on C-reactive protein/high-sensitivity C-reactive protein in adults with type 2 diabetes mellitus.

  • Grade: Low (C)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults with type 2 diabetes, what is the effect of carbohydrate (CHO) restriction compared to higher CHO diets on C-reactive protein?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Fabricatore A, Wadden T, Ebbeling C, Thomas J, Stallings V, Schwartz S, Ludwig D. Targeting dietary fat or glycemic load in the treatment of obesity and type 2 diabetes: a randomized controlled trial. Diabetes Research and Clinical Practice 2011; 92:37-45
      • Jonasson L, Guldbrand H, Lundberg A, Nystrom F. Advice to follow a low-carbohydrate diet has a favourable impact on low-grade inflammation in type 2 diabetes compared with advice to follow a low-fat diet. Annals of Medicine 2014; 46:182-187
      • Maiorino M, Bellastella G, Petrizzo M, Scappaticcio L, Giugliano D, Esposito K. Mediterranean diet cools down the inflammatory milieu in type 2 diabetes: the MÉDITA randomized controlled trial. Endocrine 2016; 54:634-641
      • Watson N, Dyer K, Buckley J, Brinkworth G, Coates A, Parfitt G, Howe P, Noakes M, Murphy K. Effects of Low-Fat Diets Differing in Protein and Carbohydrate Content on Cardiometabolic Risk Factors during Weight Loss and Weight Maintenance in Obese Adults with Type 2 Diabetes. Nutrients 2016; 8:
  • Search Plan and Results: CRDA: Overweight or Obesity and Type 2 Diabetes Mellitus 2023