Maiorino M, Bellastella G, et al. 2016

26860514

Mediterranean diet cools down the inflammatory milieu in type 2 diabetes: the MÉDITA randomized controlled trial.

Maiorino M, Bellastella G, Petrizzo M, Scappaticcio L, Giugliano D, Esposito K

Endocrine

2016

54

3

634-641

Randomized Controlled Trial

Low

30 to 75 years-old; BMI > 25k; HbA1c < 11%; sedentary (<1 hour of physical activity per week); no evidence of participation in weight-reduction programs; stable weight (+/-2 kg) in the past 6 months.

Pregnancy or breastfeeding; use of any investigational drug in the previous 3 months; use of agents affecting glycemic control (such as systemic glucocorticoids and weight-loss drugs); any condition that might compromise adherence to diet regimens; positive antibodies to glutamate decarboxylase; C-peptide levels less than 0.25 pmol/L (>1.4 mg/dL); abnormal laboratory test results, including liver enzyme levels (alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase) greater than 3 times the upper limit of normal and serum creatinine levels greater than 123.8 micromol/L (>1.4 mg/dL).

To assess whether Mediterranean diet influences both C-reactive protein (CRP) and adiponectin in newly diagnosed type 2 diabetes, and whether adherence to Mediterranean diet affects their circulating levels.

Italy

University/Hospital, Other

Second University of Naples The Associazione Salute con Stile