CRDA: Inflammatory Marker Outcomes (2023)

Author and Year:
Maiorino M, Bellastella G, et al. 2016
PubMed ID:
Article Title:
Mediterranean diet cools down the inflammatory milieu in type 2 diabetes: the MÉDITA randomized controlled trial.
Maiorino M, Bellastella G, Petrizzo M, Scappaticcio L, Giugliano D, Esposito K
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Inclusion Criteria:
30 to 75 years-old; BMI > 25k; HbA1c < 11%; sedentary (<1 hour of physical activity per week); no evidence of participation in weight-reduction programs; stable weight (+/-2 kg) in the past 6 months.
Exclusion Criteria:
Pregnancy or breastfeeding; use of any investigational drug in the previous 3 months; use of agents affecting glycemic control (such as systemic glucocorticoids and weight-loss drugs); any condition that might compromise adherence to diet regimens; positive antibodies to glutamate decarboxylase; C-peptide levels less than 0.25 pmol/L (>1.4 mg/dL); abnormal laboratory test results, including liver enzyme levels (alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase) greater than 3 times the upper limit of normal and serum creatinine levels greater than 123.8 micromol/L (>1.4 mg/dL).
Research Purpose:
To assess whether Mediterranean diet influences both C-reactive protein (CRP) and adiponectin in newly diagnosed type 2 diabetes, and whether adherence to Mediterranean diet affects their circulating levels.
Blinding efforts:
Study Location:
Source(s) of Funding:
University/Hospital, Other
Please specify names of funders:
Second University of Naples The Associazione Salute con Stile