DLM-SF: Blood Lipids (2021)

Author and Year:
Harcombe Z, Baker J, et al, 2015
PubMed ID:
Article Title:
Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis.
Harcombe Z, Baker J, Cooper S, Davies B, Sculthorpe N, DiNicolantonio J, Grace F
Open Heart
Year of publication:
Page numbers:
Study Design:
Meta-analysis or Systematic Review
Risk of Bias Assessment Rating:
Critically low
Inclusion Criteria:
Randomised dietary intervention studies; study hypothesis relating to a reduction or modification of dietary fat or cholesterol; participants were human adults; the study was a minimum of 1 year in duration; data on all-cause mortality, CHD mortality and cholesterol measurements were available
Exclusion Criteria:
Study being observational; non-randomised and/or multifactorial in design.
Research Purpose:
National dietary guidelines were introduced in 1977 and 1983, by the US and UK governments, respectively, with the ambition of reducing coronary heart disease (CHD) by reducing fat intake. To date, no analysis of the evidence base for these recommendations has been undertaken. The present study examines the evidence from randomised controlled trials (RCTs) available to the US and UK regulatory committees at their respective points of implementation.
Blinding efforts:
Not applicable
Study Location:
Source(s) of Funding:
Please specify names of funders: