Harcombe Z, Baker J, et al, 2015

25685363

Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis.

Harcombe Z, Baker J, Cooper S, Davies B, Sculthorpe N, DiNicolantonio J, Grace F

Open Heart

2015

2

1

e000196

Meta-analysis or Systematic Review

Critically low

Randomised dietary intervention studies; study hypothesis relating to a reduction or modification of dietary fat or cholesterol; participants were human adults; the study was a minimum of 1 year in duration; data on all-cause mortality, CHD mortality and cholesterol measurements were available

Study being observational; non-randomised and/or multifactorial in design.

National dietary guidelines were introduced in 1977 and 1983, by the US and UK governments, respectively, with the ambition of reducing coronary heart disease (CHD) by reducing fat intake. To date, no analysis of the evidence base for these recommendations has been undertaken. The present study examines the evidence from randomised controlled trials (RCTs) available to the US and UK regulatory committees at their respective points of implementation.

Not applicable