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DLM-SF: Replacement of Saturated Fat (2018-21)

Author and Year:
Ramsden C, Zamora D, et al. 2016
PubMed ID:
Article Title:
Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73).
Ramsden C, Zamora D, Majchrzak-Hong S, Faurot K, Broste S, Frantz R, Davis J, Ringel A, Suchindran C, Hibbeln J
BMJ (Clinical Research Ed.)
Year of publication:
Page numbers:
Study Design:
Meta-analysis or Systematic Review
Risk of Bias Assessment Rating:
Inclusion Criteria:
Serum cholesterol lowering randomized controlled trials since 1950 with publication in English that randomly assigned individual participants; provided an intervention of vegetable oil rich in linoleic acid in place of saturated fat, compared with a usual care control diet; were not confounded by the addition of large quantities of n-3 EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) or by other major concomitant interventions (such as complex changes in diet pattern) or unequal intensity of medical management (such as advice on smoking cessation or control of blood pressure); and reported deaths from coronary heart disease or all causes.
Exclusion Criteria:
Randomized controlled trials that provided large quantities of n-3 EPA and DHA or provided advice only without provision of linoleic acid rich oils from the main analysis, and studies with only biochemical or intermediate endpoints
Research Purpose:
To examine the traditional diet-heart hypothesis through recovery and analysis of previously unpublished data from the Minnesota Coronary Experiment (MCE) and to put findings in the context of existing diet-heart randomized controlled trials through a systematic review and meta-analysis.
Blinding efforts:
Not applicable
Study Location:
Not applicable
Source(s) of Funding:
Please specify names of funders:
The MCE was funded by the US Public Health Service and National Heart Institute through the R01 mechanism (grant HE09686). The intramural program of the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, and the University of North Carolina Program on Integrative Medicine (National Institutes of Health grant T-32 AT003378) supported data recovery and evaluation. The content is solely the responsibility of the authors and does not necessarily represent the offic