Oncology

Glutamine TPN (2025)

• Intervention
  In adults with hematologic cancers, what is the effect of glutamine-enriched parenteral nutrition compared to standard parenteral nutrition on length of stay?

  • Conclusion

    In adults with hematologic cancers, the effect of glutamine-enriched parenteral nutrition compared to standard parenteral nutrition on length of stay is uncertain secondary to serious risk of bias and very serious imprecision. 

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In adults with hematologic cancers, what is the effect of glutamine-enriched parenteral nutrition compared to standard parenteral nutrition on length of stay?
    • Detail
    • Worksheets
      • Blijlevens N, Donnelly J, Naber A, Schattenberg A, DePauw B. A randomised, double-blinded, placebo-controlled, pilot study of parenteral glutamine for allogeneic stem cell transplant patients. Supportive Care in Cancer 2005; 13:790-796
      • da Gama Torres H, Vilela E, da Cunha A, Goulart E, Souza M, Aguirre A, Azevedo W, Lodi F, Silva A, Bittencourt H. Efficacy of glutamine-supplemented parenteral nutrition on short-term survival following allo-SCT: a randomized study. Bone Marrow Transplantation 2008; 41:1021-1027
      • Piccirillo N, De Matteis S, Laurenti L, Chiusolo P, Sorà F, Pittiruti M, Rutella S, Cicconi S, Fiorini A, D'Onofrio G, Leone G, Sica S. Glutamine-enriched parenteral nutrition after autologous peripheral blood stem cell transplantation: effects on immune reconstitution and mucositis. Haematologica 2003; 88:192-200
      • Scheid C, Hermann K, Kremer G, Holsing A, Heck G, Fuchs M, Waldschmidt D, Herrmann H, Söhngen D, Diehl V, Schwenk A. Randomized, double-blind, controlled study of glycyl-glutamine-dipeptide in the parenteral nutrition of patients with acute leukemia undergoing intensive chemotherapy. Nutrition 2004; 20:249-254
  • Search Plan and Results: ONC: Nutrition Support for Hematologic Cancers (2025)