Glutamine TPN
Author and Year:
Blijlevens N, Donnelly J, Naber A, et al. 2005
PubMed ID:
Article Title:
A randomised, double-blinded, placebo-controlled, pilot study of parenteral glutamine for allogeneic stem cell transplant patients
Authors:
Blijlevens N, Donnelly J, Naber A, Schattenberg A, DePauw B
Journal:
Supportive Care in Cancer
Year of publication:
2005
Volume:
13
Issue:
10
Page numbers:
790-796
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
Patients aged 18-65 years admitted to receive an HLA-matched T-cell-depleted sibling graft and were able to receive myeloablative therapy with idarubicin before transplant; free of an inborn error of amino acid metabolism, insulin-dependent diabetes and inflammatory bowel disease.
Exclusion Criteria:
Not reported
Research Purpose:
The aim of this study was to determine whether glutamine-dipeptide supplementation of parenteral nutrition reduces mucosal barrier injuries.
Blinding efforts:
Randomization was performed by the hospital pharmacy and, except for the hospital pharmacist, all other personnel involved in the trial were blinded, as were the patients.
Study Location:
Nijmegen, The Netherlands
Source(s) of Funding:
Industry
Please specify names of funders:
An educational grant of Fresenius-Kabi Nederland BV, Hertogenbosch, The Netherlands.