(ONC) Glutamine TPN (2025)

Intervention
In adults with hematologic cancers, what is the effect of glutamine-enriched parenteral nutrition compared to standard parenteral nutrition on length of stay?
- Conclusion
  In adults with hematologic cancers, the effect of glutamine-enriched parenteral nutrition compared to standard parenteral nutrition on length of stay is uncertain secondary to serious risk of bias and very serious imprecision.
- Grade: Very Low (D)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults with hematologic cancers, what is the effect of glutamine-enriched parenteral nutrition compared to standard parenteral nutrition on length of stay?
  - Detail
  - Worksheets
    
    Blijlevens N, Donnelly J, Naber A, Schattenberg A, DePauw B. A randomised, double-blinded, placebo-controlled, pilot study of parenteral glutamine for allogeneic stem cell transplant patients. Supportive Care in Cancer 2005; 13:790-796
    
    da Gama Torres H, Vilela E, da Cunha A, Goulart E, Souza M, Aguirre A, Azevedo W, Lodi F, Silva A, Bittencourt H. Efficacy of glutamine-supplemented parenteral nutrition on short-term survival following allo-SCT: a randomized study. Bone Marrow Transplantation 2008; 41:1021-1027
    
    Piccirillo N, De Matteis S, Laurenti L, Chiusolo P, Sorà F, Pittiruti M, Rutella S, Cicconi S, Fiorini A, D'Onofrio G, Leone G, Sica S. Glutamine-enriched parenteral nutrition after autologous peripheral blood stem cell transplantation: effects on immune reconstitution and mucositis. Haematologica 2003; 88:192-200
    
    Scheid C, Hermann K, Kremer G, Holsing A, Heck G, Fuchs M, Waldschmidt D, Herrmann H, Söhngen D, Diehl V, Schwenk A. Randomized, double-blind, controlled study of glycyl-glutamine-dipeptide in the parenteral nutrition of patients with acute leukemia undergoing intensive chemotherapy. Nutrition 2004; 20:249-254
- Search Plan and Results: ONC: Nutrition Support for Hematologic Cancers (2025)