Hypertension

HTN: Magnesium (2015)

• Intervention
  What is the relationship between magnesium intake from food sources and blood pressure in adults with hypertension?

  • Conclusion
    Results from three studies suggest that the relationship between magnesium intake from food sources and blood pressure in adults with hypertension is unclear.
  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What is the relationship between magnesium intake from food sources and blood pressure in adults with hypertension?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Kesteloot H, Tzoulaki I, Brown IJ, Chan Q, Wijeyesekera A, Ueshima H, Zhao L, Dyer AR, Unwin RJ, Stamler J, Elliott P. Relation of urinary calcium and magnesium excretion to blood pressure. Am J Epidemiol. 2011; 174 (1): 44-51.
      • Lancaster KJ, Smiciklas-Wright H, Weltzel LB, Mitchell DC, Friedman JM, Jensen GL. Hypertension-related dietary patterns of rural older adults. Preventive Medicine, 2004; 38: 812-818.
  • Search Plan and Results: HTN: Minerals (Magnesium) 2014
     
  What is the relationship between magnesium intake from supplements and blood pressure in adults with hypertension?

  • Conclusion
    In three studies, including one meta-analysis of adults with hypertension, magnesium supplementation of 240mg to 1,000mg per day reduced systolic blood pressure by 1.0mmHg to 5.6mmHg and diastolic blood pressure by 1.0mmHg to 2.8mmHg.
  • Grade: II
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What is the relationship between magnesium intake from supplements and blood pressure in adults with hypertension?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Bayir A, Kara H, Ak A, Cander B, Kara F. Magnesium sulfate in emergency department patients with hypertension. Biol Trace Elem Res. 2009; 128: 38-44.
      • Dickinson HO, Nicolson D, Campbell F, Cook JV, Beyer FR, Ford GA, Mason J. Magnesium supplementation for the management of primary hypertension in adults (Review). Cochrane Database of Systematic Reviews. 2006; 3. Art. No.: CD004640. DOI: 10.1002/14651858.CD004640.pub2.
      • Hatzistavri LK, Sarafidis PA, Georgianos PI, Tziolas JM, Aroditis CP, Zebekakis PE, Pikilidou MI, Lasaridis AN. Oral magnesium supplementaion reduces ambulatory blood pressure in patients with mild hypertension. Am J Hypertens. 2009; 22 (10): 1,070-1,075.
  • Search Plan and Results: HTN: Minerals (Magnesium) 2014