HF: Carnitine (2007)
For the patient with heart failure, does carnitine provide beneficial outcomes?
Available evidence indicates that patients with heart failure may benefit from using carnitine. Two studies suggest that in patients with HF, oral carnitine enhances exercise capacity, peak oxygen consumption and arterial and pulmonary blood pressure. One study suggests carnitine reduces echocardiographic end-diastolic dimensions and septal separation. One study measured mortality and found survival rate improved in the carnitine group. Individuals in this study were on ACE-inhibitors. Further research on the effect of carnitine use in patients with heart failure is needed.
- Grade I means there is good evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited;
- Grade IV is Expert Opinion;
- Grade V is Not Assignable.
Evidence Summary: Carnitine and heart failure outcomes
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Anand I, Chandrashekhan Y, De Giuli F, Pasini E, Mazzoletti A, Confortini R, Ferrari R. Cardiovasc Drugs Ther. 1998; 12: 291-299.
- Rizos I. Three-year survival of patients with heart failure caused by dilatedcardiomyopathy and L-carnitine administration. Am Heart J. 2000 Feb; 139 (2 Pt. 3): S120-123.
Search Plan and Results: Carnitine and Heart Failure 2005