DLM-SF: Replacement of Saturated Fat (2018-21)

Intervention
In adults with or without cardiovascular disease, what is the association between replacement of saturated fat intake with polyunsaturated fat, monounsaturated fat, or carbohydrate intake and cardiovascular events?
- Conclusion
  In adults with or without cardiovascular disease, replacement of saturated fat intake with polyunsaturated fat intake may promote a healthy dietary pattern and may help reduce cardiovascular events. Replacement of saturated fat intake with carbohydrates or monounsaturated fat indicates little to no effect on cardiovascular events.
- Grade: Moderate (B)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults with or without cardiovascular disease, what is the association between replacement of saturated fat intake with polyunsaturated fat, monounsaturated fat, or carbohydrate intake and cardiovascular events?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Hooper L, Martin N, Jimoh O, Kirk C, Foster E, Abdelhamid A. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database of Systematic Reviews 2020; 5:CD011737
- Search Plan and Results: DLM-SF: Replacement of Saturated Fat (2021)
In adults with or without cardiovascular disease, what is the association between replacement of saturated fat intake with polyunsaturated fat, monounsaturated fat, or carbohydrate intake on all-cause mortality?
- Conclusion
  In adults, with and without existing cardiovascular disease, replacement of saturated fat intake with polyunsaturated fat, monounsaturated fat, or carbohydrate intake has little or no effect on all-cause mortality.
- Grade: Low (C)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults with or without cardiovascular disease, what is the association between replacement of saturated fat intake with polyunsaturated fat, monounsaturated fat, or carbohydrate intake on all-cause mortality?
- Search Plan and Results: DLM-SF: Replacement of Saturated Fat (2021)
In adults with or without cardiovascular disease, what is the association between replacement of saturated fat intake with polyunsaturated fat, monounsaturated fat, or carbohydrate intake on blood lipids?
- Conclusion
  In adults with or without cardiovascular disease, replacement of saturated fat intake with polyunsaturated fat intake will likely reduce total cholesterol and triglycerides. Replacement of saturated fat intake with monounsaturated fat or carbohydrates will not likely have an effect on blood lipids.
- Grade: Moderate (B)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults with or without cardiovascular disease, what is the association between replacement of saturated fat intake with polyunsaturated fat, monounsaturated fat, or carbohydrate intake on blood lipids?
- Search Plan and Results: DLM-SF: Replacement of Saturated Fat (2021)
In adults with or without cardiovascular disease, what is the association between replacement of saturated fat intake with polyunsaturated fat, monounsaturated fat, or carbohydrate intake on cardiovascular mortality?
- Conclusion
  In adults with and without existing cardiovascular disease, replacement of saturated fat intake with polyunsaturated fat, monounsaturated fat, or carbohydrate intake has little or no effect on cardiovascular mortality.
- Grade: Low (C)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults with or without cardiovascular disease, what is the association between replacement of saturated fat intake with polyunsaturated fat, monounsaturated fat, or carbohydrate intake on cardiovascular mortality?
  - Detail
  - Quality Rating Summary
    For a summary of the Quality Rating results, click here.
  - Worksheets
    
    Hooper L, Martin N, Jimoh O, Kirk C, Foster E, Abdelhamid A. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database of Systematic Reviews 2020; 5:CD011737
- Search Plan and Results: DLM-SF: Replacement of Saturated Fat (2021)
In adults with or without cardiovascular disease, what is the association between replacement of saturated fat intake with polyunsaturated fat, monounsaturated fat, or carbohydrate intake on coronary heart disease mortality?
- Conclusion
  In adults with and without existing cardiovascular disease, replacement of saturated fat intake with polyunsaturated fat, monounsaturated fat, or carbohydrate intake has little or no effect on coronary heart disease mortality.
- Grade: Low (C)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In adults with or without cardiovascular disease, what is the association between replacement of saturated fat intake with polyunsaturated fat, monounsaturated fat, or carbohydrate intake on coronary heart disease mortality?
- Search Plan and Results: DLM-SF: Replacement of Saturated Fat (2021)