AWM: Interventions in Primary Care or Outpatient Settings (2020-21)

Author and Year:
Bove K, Nilsson M, et al, 2020
PubMed ID:
Article Title:
Comprehensive treatment of microvascular angina in overweight women - a randomized controlled pilot trial.
Bove K, Nilsson M, Pedersen L, Mikkelsen N, Suhrs H, Astrup A, Prescott E
PloS One
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Low risk
Inclusion Criteria:
CMD defined as a coronary flow velocity reserve (CFVR) 26kg/m2; or BMI 25–26 and waist-hip-ratio >0.8.
Exclusion Criteria:
Severe renal failure(eGFR <30); hepatic comorbidity; chronic alcohol abuse; allergies to content of the low energy diet; atrial flutter or fibrillation at the time of stress-echocardiography; physical or mental disabilities contraindicating or hampering diet or exercise training.
Research Purpose:
We hypothesized that amelioration of risk factors for CMD would improve both angina and coronary microvascular function. We tested this hypothesis by randomizing symptomatic women with CMD and no obstructive epicardial disease to an intervention comprising weight loss, aerobic interval training (AIT), and optimal medical treatment of hypertension, dyslipidemia and diabetes versus usual care.
Blinding efforts:
Study Location:
Copenhagen, Denmark
Source(s) of Funding:
University/Hospital, Not-for-profit
Please specify names of funders:
Capital Region of Denmark Research Foundation Bispebjerg-Frederiksberg Hospital Internal Foundation Eva og Henry Frænkels MemorialFoundation Christensson-Cesons Family Foundation Department of Cardiology Bispebjerg-Frederiksberg Hospital.