Njike V, Treu J, Kela G, et al. 2021

34494112

Egg Consumption in the Context of Plant-Based Diets and Cardiometabolic Risk Factors in Adults at Risk of Type 2 Diabetes.

Njike V, Treu J, Kela G, Ayettey R, Comerford B, Siddiqui W

The Journal of Nutrition

2021

151

12

3651-3660

Randomized Crossover Trial

Some concerns

Man or postmenopausal woman age 25-75 y; nonsmoker; and at risk of T2DM as defined by fasting blood glucose > 5.6 mmol/Land <7 mmol/L or glycated hemoglobin of 5.7%-6.4%, or meeting criteria for metabolic syndrome as defined by the National Cholesterol Education Program Adult Treatment Panel III.

Allergy to eggs; anticipated inability to complete the study protocol; current eating disorder; unstable use of lipid-lowering or antihypertensive medications and/or unwilling to refrain from taking medication for 12 h before EF scanning; regular use of high doses of vitamin E (>400 IU/d) or vitamin C (>500 mg/d); consumption of fish oil, flaxseed oil, omega-3 fatty acid, and/or fiber supplement, unless willing to discontinue supplementation for the study duration; use of insulin, glucose-sensitizing medication, or vasoactive medication; unstable use of antidepressant medications; diagnosed diabetes; diagnosed sleep apnea; established CVD; coagulopathy, known bleeding diathesis, or history of clinically significant hemorrhage; current use of warfarin; substance abuse; any unstable medical condition that would limit the ability to participate fully in the trial; and the use of hormone replacement therapy.

To help determine whether eggs should be recommended as part of PBD among persons at risk of T2DM, we examined their effects on cardiometabolic risk factors. We hypothesized that including 2 eggs daily for 6 wk, compared with excluding them from PBDs, would have superior or neutral effects on endothelial function (EF) and other cardiometabolic risk factors among those at risk of T2DM.

CT, USA

Industry

American Egg Board/Egg Nutrition Center