VN: Cardiovascular Disease Risk Factors (2024)

Author and Year:
Njike V, Treu J, Kela G, et al. 2021
PubMed ID:
Article Title:
Egg Consumption in the Context of Plant-Based Diets and Cardiometabolic Risk Factors in Adults at Risk of Type 2 Diabetes.
Njike V, Treu J, Kela G, Ayettey R, Comerford B, Siddiqui W
The Journal of Nutrition
Year of publication:
Page numbers:
Study Design:
Randomized Crossover Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
Man or postmenopausal woman age 25-75 y; nonsmoker; and at risk of T2DM as defined by fasting blood glucose > 5.6 mmol/Land <7 mmol/L or glycated hemoglobin of 5.7%-6.4%, or meeting criteria for metabolic syndrome as defined by the National Cholesterol Education Program Adult Treatment Panel III.
Exclusion Criteria:
Allergy to eggs; anticipated inability to complete the study protocol; current eating disorder; unstable use of lipid-lowering or antihypertensive medications and/or unwilling to refrain from taking medication for 12 h before EF scanning; regular use of high doses of vitamin E (>400 IU/d) or vitamin C (>500 mg/d); consumption of fish oil, flaxseed oil, omega-3 fatty acid, and/or fiber supplement, unless willing to discontinue supplementation for the study duration; use of insulin, glucose-sensitizing medication, or vasoactive medication; unstable use of antidepressant medications; diagnosed diabetes; diagnosed sleep apnea; established CVD; coagulopathy, known bleeding diathesis, or history of clinically significant hemorrhage; current use of warfarin; substance abuse; any unstable medical condition that would limit the ability to participate fully in the trial; and the use of hormone replacement therapy.
Research Purpose:
To help determine whether eggs should be recommended as part of PBD among persons at risk of T2DM, we examined their effects on cardiometabolic risk factors. We hypothesized that including 2 eggs daily for 6 wk, compared with excluding them from PBDs, would have superior or neutral effects on endothelial function (EF) and other cardiometabolic risk factors among those at risk of T2DM.
Blinding efforts:
Study Location:
Source(s) of Funding:
Please specify names of funders:
American Egg Board/Egg Nutrition Center