PDM: Prediabetes (2013)

PDM: Prediabetes (2013)

• Assessment
  In individuals with prediabetes, what is the impact of glycemic index/load, independent of weight loss, on glycemic-related outcomes (such as fasting blood glucose, random blood glucose, two-hour post-prandial blood glucose, A1C)?

  • Conclusion

    One intervention study and one feeding study regarding the relative reduction of glycemic index/load reported a significant decrease in postprandial glycemic outcomes in individuals with prediabetes.

    Additional longer-term intervention studies are needed to ascertain the effects of relative reduction as well as low glycemic index/load values on glycemic outcomes in individuals with prediabetes.

     

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In individuals with prediabetes, what is the impact of glycemic index/load, independent of weight loss, on glycemic-related outcomes (such as fasting blood glucose, random blood glucose, 2-hour postprandial blood glucose, A1C)?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Perala MM, Hatonen KA, Virtamo J, Eriksson JG, Sinkko HK, Sundvall J, Valsta LM. Impact of overweight and glucose tolerance on postprandial responses to high- and low-glycaemic index meals. Br J Nutr. 2011; 105(11): 1,627-1,634.
      • Wolever TM, Mehling C. Long-term effect of varying the source or amount of dietary carbohydrate on postprandial plasma glucose, insulin, triacylglycerol and free fatty acid concentrations in subjects with impaired glucose tolerance. Am J Clin Nutr. 2003; 77: 612-621.
  • Search Plan and Results: PDM: Glycemic Index/Load and Prediabetes 2012
     
  In individuals with prediabetes, what is the impact of glycemic index/load, independent of weight loss, on lipid outcomes (HDL, TG)?

  • Conclusion

    One intervention study and one feeding study regarding the relative reduction of glycemic index/load reported inconclusive results regarding lipid outcomes in individuals with prediabetes.

    Additional longer-term intervention studies are needed to ascertain the effects of relative reduction as well as low glycemic index/load values on lipid outcomes in individuals with prediabetes.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In individuals with prediabetes, what is the impact of glycemic index/load, independent of weight loss, on lipid outcomes (HDL, TG)?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Perala MM, Hatonen KA, Virtamo J, Eriksson JG, Sinkko HK, Sundvall J, Valsta LM. Impact of overweight and glucose tolerance on postprandial responses to high- and low-glycaemic index meals. Br J Nutr. 2011; 105(11): 1,627-1,634.
      • Wolever TM, Mehling C. Long-term effect of varying the source or amount of dietary carbohydrate on postprandial plasma glucose, insulin, triacylglycerol and free fatty acid concentrations in subjects with impaired glucose tolerance. Am J Clin Nutr. 2003; 77: 612-621.
  • Search Plan and Results: PDM: Glycemic Index/Load and Prediabetes 2012
     
• Intervention
  In individuals with prediabetes, what is the impact of glycemic index/load, independent of weight loss, on anthropometric outcomes (WC, WHR)?

  • Conclusion

    There were no studies identified to evaluate the relative reduction of glycemic index/load on anthropometric outcomes in individuals with prediabetes.

    Intervention studies are needed to ascertain the effects of relative reduction as well as low glycemic index/load values on anthropometric outcomes in individuals with prediabetes.

     

  • Grade: V
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Search Plan and Results: PDM: Glycemic Index/Load and Prediabetes 2012
     
  In individuals with prediabetes, what is the impact of glycemic index/load, independent of weight loss, on blood pressure?

  • Conclusion

    There were no studies identified to evaluate the relative reduction of glycemic index/load on blood pressure in individuals with prediabetes.

    Intervention studies are needed to ascertain the effects of relative reduction as well as low glycemic index/load values on blood pressure in individuals with prediabetes.

  • Grade: V
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Search Plan and Results: PDM: Glycemic Index/Load and Prediabetes 2012