Bo Y, Liu C, et al. 2019

29395372

A high whey protein, vitamin D and E supplement preserves muscle mass, strength, and quality of life in sarcopenic older adults: A double-blind randomized controlled trial.

Bo Y, Liu C, Ji Z, Yang R, An Q, Zhang X, You J, Duan D, Sun Y, Zhu Y, Cui H, Lu Q

Clinical Nutrition (Edinburgh, Scotland)

2019

38

1

159-164

Randomized Controlled Trial

Low risk

60-85 years old with sarcopenia (determined by relative skeletal mass index, handgrip strength or usual 6 m gait speed).

Mental disorders; disabilities that significantly affect the data collected, such as severe deafness, blindness, severe somatic diseases (diabetes with severe complications, patients with severe renal disease, or tumor); participating in other clinical trials; taking whey protein, vitamin D or vitamin E supplements; other reasons that are not suitable for clinical trials

Therefore, we inferred that combined supplementation of whey protein, vitamin D and E contributes to the improvements of muscle strength and function and the promoting of muscle protein synthesis. The efficacy of this concept was explored by comparing to an isocaloric placebo product for improvements of muscle mass (RSMI), muscle strength (handgrip strength), physical function (6-m gait speed, chair stand test, and timed-up-and-go test), blood biochemical indexes, and quality of life.

The randomization sequence was computer-generated by a blinded statistician who was not involved in the conducting of the study. The supplement and placebo were similar in taste and appearance. Outcomes were measured by blinded research staff.

China (assume Zhengzhou, Henan, China)

Not-for-profit

Danone Institute (link to Danone food company)