MiOA: Intervention: Community: Oral Nutrition Supplements (2023)

Author and Year:
Bo Y, Liu C, et al. 2019
PubMed ID:
Article Title:
A high whey protein, vitamin D and E supplement preserves muscle mass, strength, and quality of life in sarcopenic older adults: A double-blind randomized controlled trial.
Bo Y, Liu C, Ji Z, Yang R, An Q, Zhang X, You J, Duan D, Sun Y, Zhu Y, Cui H, Lu Q
Clinical Nutrition (Edinburgh, Scotland)
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Low risk
Inclusion Criteria:
60-85 years old with sarcopenia (determined by relative skeletal mass index, handgrip strength or usual 6 m gait speed).
Exclusion Criteria:
Mental disorders; disabilities that significantly affect the data collected, such as severe deafness, blindness, severe somatic diseases (diabetes with severe complications, patients with severe renal disease, or tumor); participating in other clinical trials; taking whey protein, vitamin D or vitamin E supplements; other reasons that are not suitable for clinical trials
Research Purpose:
Therefore, we inferred that combined supplementation of whey protein, vitamin D and E contributes to the improvements of muscle strength and function and the promoting of muscle protein synthesis. The efficacy of this concept was explored by comparing to an isocaloric placebo product for improvements of muscle mass (RSMI), muscle strength (handgrip strength), physical function (6-m gait speed, chair stand test, and timed-up-and-go test), blood biochemical indexes, and quality of life.
Blinding efforts:
The randomization sequence was computer-generated by a blinded statistician who was not involved in the conducting of the study. The supplement and placebo were similar in taste and appearance. Outcomes were measured by blinded research staff.
Study Location:
China (assume Zhengzhou, Henan, China)
Source(s) of Funding:
Please specify names of funders:
Danone Institute (link to Danone food company)