MiOA: Intervention: Post-Discharge: Oral Nutrition Supplements (2023)

Author and Year:
Edington J, Barnes R, et al. 2004
PubMed ID:
Article Title:
A prospective randomised controlled trial of nutritional supplementation in malnourished elderly in the community: clinical and health economic outcomes.
Authors:
Edington J, Barnes R, Bryan F, Dupree E, Frost G, Hickson M, Lancaster J, Mongia S, Smith J, Torrance A, West R, Pang F, Coles S
Journal:
Clinical Nutrition (Edinburgh, Scotland)
Year of publication:
2004
Volume:
23
Issue:
2
Page numbers:
195-204
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
High
Inclusion Criteria:
Age 65 years or greater; discharged from hospital with either (1) a BMI <20 or (2) a BMI of 20 or greater but <25 with documented evidence of weight loss of 10% or more of their body weight in the 6 months prior to the study period or 5% or more in the 3 months prior to the study period; enrolled between October 2000 and September 2001 and a patient at one of four participating hospitals; score of 7 or greater on the Abbreviated Mental Test; written informed consent.
Exclusion Criteria:
Incapable of taking study supplements to provide a minimum of 600 kcal/day in addition to usual food intake; could not stand to be weighed; intolerant to any of the ingredients in the study supplements; history of diabetes, hyperglycemia, or chronic renal failure; required total parenteral nutrition or enteral feeds as sole source of nutrition; prescribed supplements during the last week of their hospital stay.
Research Purpose:
To determine whether providing short-term supplemental nutrition to a heterogeneous group of elderly malnourished patients after discharge from hospital improves body weight and hence BMI, and handgrip strength. An additional objective was to determine if supplemental nutrition improves quality of life and mortality rates, or reduces the numbers of prescriptions and other healthcare resources required by malnourished patients who receive supplements when compared to those who do not.
Blinding efforts:
Randomization accomplished using envelopes prepared by statistician. Participants aware of group assignment; likely researchers also aware of participants' group assignment.
Study Location:
United Kingdom
Source(s) of Funding:
Industry
Please specify names of funders:
Abbott Laboratories, Maidenhead Berkshire, UK Participating hospitals: North Staffordshire Hospital NHS Trust, Stoke on Trent; Hammersmith Hospital, Hammersmith Hospitals NHS Trust, London; The Newcastle upon Tyne Hospitals NHS Trust.