Kim H, Kojima N, et al, 2021

32978751

The additive effects of exercise and essential amino acid on muscle mass and strength in community-dwelling older Japanese women with muscle mass decline, but not weakness and slowness: a randomized controlled and placebo trial.

Kim H,Kojima N,Uchida R,Somekawa S,Inoue N,Kobayashi H,Osuka Y

Aging clinical and experimental research

2021

33

7

1841-1852

Randomized Controlled Trial

Low risk

Elderly women over 65 years old; ability and willingness to participate in an exercise class once a week, as well as perform a predetermined home-based exercise program; agree to the contents of the study and consent to participation/

Prohibited from exercising suggested or mandated by a physician; daily fish and meat intake; skeletal mass index (SMI) under 5.7 kg/m2 , with grip strength less than 18.0 kg, or walking speed less than 1.0 m/s; soy allergy; severe low back pain and/or knee pain, cardiac, renal, and/or liver dysfunction that may interfere with proper exercise performance; systolic blood pressure (BP) higher than 180 mmHg and diastolic BP higher than 100 mmHg; daily supplement (other than the study supplement) intake; difficulty measuring muscle mass and grip strength; any person who the principal investigator deemed unfit for participation based on health concerns.

To investigate the additional effects of exercise and essential amino acid supplementation on muscle mass, strength, and physical performance in older Japanese women with muscle mass decline, but not weakness and slowness.

The allocation sequence was concealed from the study coordinator, and data collection was conducted by separate physical therapy staff members who were also blind to the allocation of treatments.

Japan

Industry

Ajinomoto Consigned Research Fund