MiOA: Intervention: Long-Term Care: Oral Nutrition Supplements (2023)
Author and Year:
Fiatararone MA, O'Neill E, et al. 1994
PubMed ID:
Article Title:
Exercise training and nutritional supplementation for physical frailty in very elderly people.
Authors:
Fiatarone M, O'Neill E, Ryan N, Clements K, Solares G, Nelson M, Roberts S, Kehayias J, Lipsitz L, Evans W
Journal:
The New England Journal of Medicine
Year of publication:
1994
Volume:
330
Issue:
25
Page numbers:
1769-1775
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
Resident of Hebrew Rehabilitation Center for the Aged; age over 70 years; ability to walk 6 meters; informed written consent.
Exclusion Criteria:
Severe cognitive impairment; rapidly progressive or terminal illness; acute illness or unstable chronic illness; myocardial infarction; fracture of a lower extremity within the six months before the study; insulin dependent diabetes mellitus; on a weight loss diet or undergoing resistance training at the time of enrollment; tests of muscle strength revealed a musculoskeletal or cardiovascular abnormality.
Research Purpose:
We hypothesized that physical frailty is partially mediated by skeletal muscle disuse and marginal nutritional intake, and should therefore be reduced by interventions designed to reverse these deficits.
Blinding efforts:
The oral nutritional supplement (ONS) and placebo ONS were administered in unmarked containers by the nursing staff, who were unaware of the contents of the containers and the group assignment.
Study Location:
Hebrew Rehabilitation Center for the Aged, Boston, Massachusetts
Source(s) of Funding:
Government, Industry, Not-for-profit
Please specify names of funders:
National Institute of Aging, Agricultural Research Service, Public Health Service
Ross Laboratories (provided ONS)
Brookdale Foundation