MiOA: Intervention: Long-Term Care: Oral Nutrition Supplements (2023)
Author and Year:
Abe S, Ezaki O, Suzuki M. 2016
PubMed ID:
Article Title:
Medium-Chain Triglycerides in Combination with Leucine and Vitamin D Increase Muscle Strength and Function in Frail Elderly Adults in a Randomized Controlled Trial.
Authors:
Abe S, Ezaki O, Suzuki M
Journal:
The Journal of Nutrition
Year of publication:
2016
Volume:
146
Issue:
5
Page numbers:
1017-1026
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
Resided in a nursing home; required special care from a helper.
Exclusion Criteria:
BMI (in kg/m2) >23 (to avoid a further increase in body weight); 200 mg/dL, blood creatinine concentration of >1.5 mg/dL, or C-reactive protein concentration of >2.0 mg/dL; allergy to the supplements used in the study.
Research Purpose:
To determine whether supplementation with a combination of small amounts of leucine-enriched EAAs (40% leucine in 3 g EAAs), cholecalciferol (20mg, 800 IU), and MCTs (6 g) could achieve a synergistic or additive improvement in skeletal muscle function.
Blinding efforts:
Participants in the intervention and control groups could not be blinded. However, in the intervention groups, the participants could not distinguish between the two different supplements. Examiners who oversaw the walking speed test were unaware of each participant's group. Other anthropometric and physical performance tests were conducted by an expert who was aware of the participant's group assignment.
Study Location:
Day Care SKY facility in Yokohama, Japan
Source(s) of Funding:
Not reported
Please specify names of funders:
NA