CRDA: Other Outcomes (2023)

Author and Year:
Sato J, Kanazawa A, et al. 2017
PubMed ID:
Article Title:
A randomized controlled trial of 130 g/day low-carbohydrate diet in type 2 diabetes with poor glycemic control.
Sato J, Kanazawa A, Makita S, Hatae C, Komiya K, Shimizu T, Ikeda F, Tamura Y, Ogihara T, Mita T, Goto H, Uchida T, Miyatsuka T, Takeno K, Shimada S, Ohmura C, Watanabe T, Kobayashi K, Miura Y, Iwaoka M, Hirashima N, Fujitani Y, Watada H
Clinical Nutrition (Edinburgh, Scotland)
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
T2DM; age >20 but 7.5% for more than 3 months, with HbA1c fluctuations within +/- 0.5%; BMI >23 kg/m2; had received at least two educational programs on calorie-restricted diets from dietitians.
Exclusion Criteria:
Proliferative retinopathy; severe neuropathy; serious kidney disease (serum creatinine level >2.0 mg/dL and/or with microalbuminuria); serious liver disease excluding fatty liver (aspartate aminotransferase and/or alanine aminotransferase levels >100 IU/L); acute heart failure within 3 months or apparent chronic heart failure; active malignancy; serious pancreatic disease; pregnancy; serious infectious disease; trauma injury; alcohol dependency; not suitable for the study.
Research Purpose:
Evaluate the safety and efficacy of 130g/day low-carb diet in Japanese patients with poorly-controlled T2DM who had received repeated education programs on calorie-restricted diets.
Blinding efforts:
Study Location:
Juntendo University Hospital, Tokyo, Japan
Source(s) of Funding:
Please specify names of funders:
Mishima Kaiun Memorial Foundation