CRDA: Other Outcomes (2023)

Author and Year:
Watson N, Dyer K, et al. 2018
PubMed ID:
Article Title:
Comparison of two low-fat diets, differing in protein and carbohydrate, on psychological wellbeing in adults with obesity and type 2 diabetes: a randomised clinical trial.
Watson N, Dyer K, Buckley J, Brinkworth G, Coates A, Parfitt G, Howe P, Noakes M, Murphy K
Nutrition Journal
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
Diagnosed with T2DM; aged 18-70 years; HbA1c between 6.5-10.5% at screening; BMI greater than 25 kg/m2; weight > 135kg (maximum capacity for dual X-ray absorptiometry [DEXA]; non-smoker for more than 6 months; proficient in written and spoken English (to perform the cognitive tests); age-appropriate cognitive abilities (determined using the DemTect questionnaire); completed diet and lifestyle questionnaire requesting information on current disease management, medical conditions, medications, weight, smoking status, dietary requirements and ability to exercise; approval to participate from personal medical provider; written informed consent.
Exclusion Criteria:
Liver, kidney, gastrointestinal or cardiovascular disease; respiratory disease (apart from stable asthma); retinopathy; malignancy (within last 6 months); proteinuria; uncontrolled hypertension (>170/100); taking medication for a neurological or psychiatric condition (except stable antidepressants > 3 months); neurological or psychiatric condition; history of head or brain injury; musculoskeletal injury or peripheral vascular disease sufficient to impede exercise; undertaking a weight loss program or taking appetite suppressants; pregnant or lactating; unable to participate in the trial for 6 months; participated in another study within last 30 days.
Research Purpose:
To compare the effects of isocaloric higher protein (HP) and higher carbohydrate (HC) diets, combined with regular moderate intensity exercise, on psychological wellbeing and health related quality of life (HRQoL) outcomes in overweight and obese adults with type 2 diabetes (T2D) during a 12-week active weight loss phase followed by a 12-week weight maintenance phase where weight was stabilized.
Blinding efforts:
Allocated to treatment by an investigator with no participant contact using minimization stratified for age, gender, and BMI.
Study Location:
Adelaide, Australia
Source(s) of Funding:
Government, Industry
Please specify names of funders:
Co-operative Research Centre for High Integrity Australian Pork; food donations: Australian Health and Nutrition Ltd (Sanitarium), Fonterra Brands Australia, Almond Board of Australia