Studies have shown that both natural and wheat starch-based gluten-free diets produce similar histological and clinical recovery in people with celiac disease. Overall compliance with a gluten-free diet may be more important than the specific type of diet followed (i.e., natural or wheat starch-based), as evidenced by the incomplete bowel mucosal recovery and positive serology generally seen in those study subjects with dietary lapses. Further research regarding the acceptability of wheat starch-based gluten-free foods and the threshold level of tolerance for gluten is needed.
