Celiac Disease

CD: Oats (2021)

• Intervention
  In patients with celiac disease, what are the effects of oats, compared to a control, on anthropometrics?

  • Conclusion

    In healthy patients with celiac disease, there was no significant improvement in body mass index (BMI) among participants who consumed oats as a part of a gluten-free diet when compared to a control group. (Grade III or Very Low)

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of oats, compared to a control, on anthropometrics?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Kaukinen K, Collin P, Huhtala H, Mäki M. Long-term consumption of oats in adult celiac disease patients. Nutrients 2013; 5:4380-4389
      • Lionetti E, Gatti S, Galeazzi T, Caporelli N, Francavilla R, Cucchiara S, Roggero P, Malamisura B, Iacono G, Tomarchio S, Kleon W, Restani P, Brusca I, Budelli A, Gesuita R, Carle F, Catassi C. Safety of Oats in Children with Celiac Disease: A Double-Blind, Randomized, Placebo-Controlled Trial. Journal of Pediatrics 2018; 194:116-122.e2
  • Search Plan and Results: CD: Oats 2020
     
  In patients with celiac disease, what are the effects of oats, compared to a control, on celiac disease-related antibodies, inflammatory indicators and immunological indicators?

  • Conclusion

    In healthy patients with celiac disease, there was no significant difference in celiac disease-related antibodies, inflammatory indicators and immunological indicators, such as transglutaminase IgA, AGA, transglutaminase IgG or intraepithelial lymphocytes between participants who consumed a gluten-free diet with oats and a gluten-free diet without oats. (Grade III or Very Low)

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of oats, compared to a control, on celiac disease-related antibodies and inflammatory and immunological indicators?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Aaltonen K, Laurikka P, Huhtala H, Maki M, Kaukinen K, Kurppa K. The long-term consumption of oats in celiac disease patients is safe: a large cross-sectional study. Nutrients 2017; 9:611-621
      • Guttormsen V, Løvik A, Bye A, Bratlie J, Mørkrid L, Lundin K. No induction of anti-avenin IgA by oats in adult, diet-treated coeliac disease. Scandinavian Journal of Gastroenterology 2008; 43:161-5
      • Kaukinen K, Collin P, Huhtala H, Mäki M. Long-term consumption of oats in adult celiac disease patients. Nutrients 2013; 5:4380-4389
      • Kemppainen T, Janatuinen E, Holm K, Kosma V, Heikkinen M, Mäki M, Laurila K, Uusitupa M, Julkunen R. No observed local immunological response at cell level after five years of oats in adult coeliac disease. Scandinavian Journal of Gastroenterology 2007; 42:54-59
      • Koskinen O, Villanen M, Korponay-Szabo I, Lindfors K, Mäki M, Kaukinen K. Oats do not induce systemic or mucosal autoantibody response in children with coeliac disease. Journal of Pediatric Gastroenterology and Nutrition 2009; 48:559-565
      • Lionetti E, Gatti S, Galeazzi T, Caporelli N, Francavilla R, Cucchiara S, Roggero P, Malamisura B, Iacono G, Tomarchio S, Kleon W, Restani P, Brusca I, Budelli A, Gesuita R, Carle F, Catassi C. Safety of Oats in Children with Celiac Disease: A Double-Blind, Randomized, Placebo-Controlled Trial. Journal of Pediatrics 2018; 194:116-122.e2
  • Search Plan and Results: CD: Oats 2020
     
  In patients with celiac disease, what are the effects of oats, compared to a control, on nutrition-related laboratory measures?

  • Conclusion

    In healthy adults with celiac disease, there was a significant improvement in nutrition-related laboratory measures, including P-total proteins, P-albumin, P-total cholesterol, S-folate, P-ALAT, P-phosphorus, P-bilirubin and P-ASAT, after participants with celiac disease engaged in an oat-challenge in comparison to their pre-oat challenge values. (Grade III or Very Low)

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of oats, compared to a control, on nutrition-related laboratory measures?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Løvik A, Gjøen AU, Mørkrid L, Guttormsen V, Ueland T, Lundin KEA. Oats in a strictly gluten-free diet is associated with decreased gluten intake and increased serum bilirubin. European e-Journal of Clinical Nutrition and Metabolism 2009; 4:e315-e320
  • Search Plan and Results: CD: Oats 2020
     
  In patients with celiac disease, what are the effects of oats, compared to a control, on gastrointestinal health and gastrointestinal symptoms?

  • Conclusion

    In healthy adults with celiac disease, oat intake has mixed effects on gastrointestinal symptoms and indicators of overall gastrointestinal health. (Grade III or Very Low)

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of oats, compared to a control, on gastrointestinal health and gastrointestinal symptoms?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Aaltonen K, Laurikka P, Huhtala H, Maki M, Kaukinen K, Kurppa K. The long-term consumption of oats in celiac disease patients is safe: a large cross-sectional study. Nutrients 2017; 9:611-621
      • Gatti S, Caporelli N, Galeazzi T, Francavilla R, Barbato M, Roggero P, Malamisura B, Iacono G, Budelli A, Gesuita R, Catassi C, Lionetti E. Oats in the diet of children with celiac disease: preliminary results of a double-blind, randomized, placebo-controlled multicenter Italian study. Nutrients 2013; 5:4653-4664
      • Kaukinen K, Collin P, Huhtala H, Mäki M. Long-term consumption of oats in adult celiac disease patients. Nutrients 2013; 5:4380-4389
      • Koskinen O, Villanen M, Korponay-Szabo I, Lindfors K, Mäki M, Kaukinen K. Oats do not induce systemic or mucosal autoantibody response in children with coeliac disease. Journal of Pediatric Gastroenterology and Nutrition 2009; 48:559-565
      • Lionetti E, Gatti S, Galeazzi T, Caporelli N, Francavilla R, Cucchiara S, Roggero P, Malamisura B, Iacono G, Tomarchio S, Kleon W, Restani P, Brusca I, Budelli A, Gesuita R, Carle F, Catassi C. Safety of Oats in Children with Celiac Disease: A Double-Blind, Randomized, Placebo-Controlled Trial. Journal of Pediatrics 2018; 194:116-122.e2
  • Search Plan and Results: CD: Oats 2020
     
  In patients with celiac disease, what are the effects of oats, compared to a control, on gluten-free diet adherence or compliance?

  • Conclusion

    In adults with celiac disease, the introduction of oats into a gluten-free diet as a part of an oat challenge was associated with a significant reduction in gluten intake in comparison to gluten intake of those participants before the oat challenge. However, in a separate study, there was no difference in the self-reported adherence to a gluten-free diet among healthy adults who reported consuming oats as a part of a gluten-free diet in comparison to healthy adults who reported eliminating oats from their diet. (GRADE III or Very Low)

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of oats, compared to a control, on gluten-free diet adherence or compliance?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Aaltonen K, Laurikka P, Huhtala H, Maki M, Kaukinen K, Kurppa K. The long-term consumption of oats in celiac disease patients is safe: a large cross-sectional study. Nutrients 2017; 9:611-621
      • Løvik A, Gjøen AU, Mørkrid L, Guttormsen V, Ueland T, Lundin KEA. Oats in a strictly gluten-free diet is associated with decreased gluten intake and increased serum bilirubin. European e-Journal of Clinical Nutrition and Metabolism 2009; 4:e315-e320
  • Search Plan and Results: CD: Oats 2020
     
  In patients with celiac disease, what are the effects of oats, compared to a control, on dietary intake?

  • Conclusion

    In adults with celiac disease, there was a significant increase in dietary fiber intake among participants who consumed oats as a component of a gluten-free diet in comparison to participants who did not consume oats as a component of a gluten-free diet. (Very Low or GRADE III)

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of oats, compared to a control, on dietary intake?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Kaukinen K, Collin P, Huhtala H, Mäki M. Long-term consumption of oats in adult celiac disease patients. Nutrients 2013; 5:4380-4389
      • Løvik A, Gjøen AU, Mørkrid L, Guttormsen V, Ueland T, Lundin KEA. Oats in a strictly gluten-free diet is associated with decreased gluten intake and increased serum bilirubin. European e-Journal of Clinical Nutrition and Metabolism 2009; 4:e315-e320
  • Search Plan and Results: CD: Oats 2020
     
  In patients with celiac disease, what are the effects of oats, compared to a control, on quality of life?

  • Conclusion

    In healthy adults with celiac disease, patients who consumed oats as a component of a gluten-free diet had significantly higher scores on assessments of physical role limitations and general health in comparison to patients who did not consume oats. There was no difference in general psychological well-being between groups. (Grade III or Very Low)

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of oats, compared to a control, on quality of life?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Aaltonen K, Laurikka P, Huhtala H, Maki M, Kaukinen K, Kurppa K. The long-term consumption of oats in celiac disease patients is safe: a large cross-sectional study. Nutrients 2017; 9:611-621
  • Search Plan and Results: CD: Oats 2020