Celiac Disease

CD: Supplements (2021)

• Intervention
  In patients with celiac disease, what are the effects of supplements (e.g., calcium, iron, B vitamins, zinc, copper, multivitamin), compared to a control, on anthropometrics?

  • Conclusion

    In zinc-deficient children with celiac disease, there was no effect on weight gain between the group who received a zinc supplement in addition to a gluten-free diet and those who just received a gluten-free diet. (Moderate)

  • Grade: Moderate (B)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of supplements (e.g., calcium, iron, B vitamins, zinc, copper, multivitamin), compared to a control, on anthropometrics?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Negi K, Kumar R, Sharma L, Datta S, Choudhury M, Kumar P. Serum zinc, copper and iron status of children with coeliac disease on three months of gluten-free diet with or without four weeks of zinc supplements: a randomised controlled trial. Tropical Doctor 2018; 48:112-116
  • Search Plan and Results: CD: Supplements 2020
     
  In patients with celiac disease, what are the effects of supplements (e.g., calcium, iron, B vitamins, zinc, copper, multivitamin), compared to a control, on nutrition-related laboratory measures?

  • Conclusion

    In healthy patients with celiac disease, there was a significant increase in plasma hemoglobin, ferritin, vitamin B6, folate, vitamin B12 and a reduction in homocysteine and occurrence of zinc deficiency among celiac patients who received a supplement in comparison to those who received a placebo or did not take a supplement. There was no difference in serum L-carnitine levels between celiac patients who received a supplement and those who received a placebo.

    [Grade III or Very Low.]

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of supplements (e.g., calcium, iron, B vitamins, zinc, copper, multivitamin), compared to a control, on nutrition-related laboratory measures ?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Ciacci C, Peluso G, Iannoni E, Siniscalchi M, Iovino P, Rispo A, Tortora R, Bucci C, Zingone F, Margarucci S, Calvani M. L-Carnitine in the treatment of fatigue in adult celiac disease patients: a pilot study. Digestive and Liver Disease 2007; 39:922-928
      • Hadithi M, Mulder C, Stam F, Azizi J, Crusius J, Peña A, Stehouwer C, Smulders Y. Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease. World Journal of Gastroenterology 2009; 15:955-60
      • Hallert C, Svensson M, Tholstrup J, Hultberg B. Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet. Alimentary Pharmacology & Therapeutics 2009; 29:811-816
      • Negi K, Kumar R, Sharma L, Datta S, Choudhury M, Kumar P. Serum zinc, copper and iron status of children with coeliac disease on three months of gluten-free diet with or without four weeks of zinc supplements: a randomised controlled trial. Tropical Doctor 2018; 48:112-116
      • Rawal P, Thapa B, Prasad R, Prasad K, Nain C, Singh K. Zinc supplementation to patients with celiac disease--is it required?. Journal of Tropical Pediatrics 2010; 56:391-397
  • Search Plan and Results: CD: Supplements 2020
     
  In patients with celiac disease, what are the effects of supplements (e.g., calcium, iron, B vitamins, zinc, copper, multivitamin), compared to a control, on quality of life?

  • Conclusion

    In healthy adults with celiac disease, there was a greater reduction in self-reported fatigue among participants who received supplements in comparison to participants who received a placebo, but there was no significant difference between groups in measures of other indicators of quality of life.

    [Grade III or Very Low]

  • Grade: Very Low (D)
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: In patients with celiac disease, what are the effects of supplements (e.g., calcium, iron, B vitamins, zinc, copper, multivitamin), compared to a control, on quality of life?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Ciacci C, Peluso G, Iannoni E, Siniscalchi M, Iovino P, Rispo A, Tortora R, Bucci C, Zingone F, Margarucci S, Calvani M. L-Carnitine in the treatment of fatigue in adult celiac disease patients: a pilot study. Digestive and Liver Disease 2007; 39:922-928
      • Hallert C, Svensson M, Tholstrup J, Hultberg B. Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet. Alimentary Pharmacology & Therapeutics 2009; 29:811-816
  • Search Plan and Results: CD: Supplements 2020