CD: Gluten-free Diet (2021)

Intervention
In patients with celiac disease, what are the effects of gluten-free diet (GFD), in comparison to a control or adherence to a gluten-free diet, on anthropometrics?
In patients with celiac disease, what are the effects of gluten-free diet (GFD), in comparison to a control or adherence to a gluten-free diet, on indicators of bone metabolism?
- Conclusion
  The effect of a gluten-free diet (GFD) on bone mineral density is inconclusive; however, adherence to a GFD has a positive effect on bone mineral density in children with celiac disease. (Low or GRADE III)
- Grade: Low (C)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on indicators of bone metabolism?
- Search Plan and Results: CD: Gluten Free Diet 2020
In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on nutrition-related laboratory measures?
- Conclusion
  A gluten-free diet (GFD) and GFD adherence may not have an effect on select nutrition-related laboratory measures, except for ferritin and zinc, which were negatively impacted by GFD non-adherence. (Low or GRADE III)
- Grade: Low (C)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on nutrition-related laboratory measures?
- Search Plan and Results: CD: Gluten Free Diet 2020
In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on indicators of gastrointestinal health and gastrointestinal symptoms?
- Conclusion
  A gluten-free diet (GFD) may result in an improvement of indicators of gastrointestinal health and gastrointestinal symptoms among patients with celiac disease; however, there is limited current evidence to suggest the same for GFD adherence. (Low or GRADE III)
- Grade: Low (C)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on indicators of gastrointestinal health and gastrointestinal symptoms?
- Search Plan and Results: CD: Gluten Free Diet 2020
In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on dietary intake?
- Conclusion
  A gluten-free diet (GFD) in comparison to a control may have a positive effect on dietary intake quality among patients with celiac disease, but the positive effect was not seen with varying adherence levels to a GFD. (Low or GRADE III)
- Grade: Low (C)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on dietary intake?
- Search Plan and Results: CD: Gluten Free Diet 2020
In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on celiac disease-related antibodies, inflammatory and immunological indicators?
- Conclusion
  A gluten-free diet (GFD) and adherence to a GFD are associated with improved celiac disease-related antibodies, inflammatory and immunological indicators (Low or GRADE III).
- Grade: Low (C)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on celiac disease-related antibodies, inflammatory and immunological indicators?
- Search Plan and Results: CD: Gluten Free Diet 2020
In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on indicators of quality of life?
- Conclusion
  The evidence suggests that a gluten-free diet (GFD) and greater adherence to a GFD may improve quality of life among patients with celiac disease, but the evidence is unclear (Very low or GRADE III).
- Grade: Very Low (D)
  - Grade I means there is Good/Strong evidence supporting the statement;
  - Grade II is Fair;
  - Grade III is Limited/Weak;
  - Grade IV is Expert Opinion Only;
  - Grade V is Not Assignable.
  - High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
  - Moderate (B) means we are moderately confident in the effect estimate;
  - Low (C) means our confidence in the effect estimate is limited;
  - Very Low (D) means we have very little confidence in the effect estimate.
  - Ungraded means a grade is not assignable.
- Evidence Summary: In patients with celiac disease, what are the effects of gluten-free diet (GFD) in comparison to a control or adherence to a gluten-free diet, on indicators of quality of life?
- Search Plan and Results: CD: Gluten Free Diet 2020