What is the long-term effectiveness in people with celiac disease of following a gluten-free dietary pattern on neurological symptoms?
Several studies have reported that people with celiac disease are more likely to experience neurological symptoms such as depression, cerebellar ataxia, headaches and migraines, and neuropathy than healthy controls. Early diagnosis and compliance with a gluten-free dietary pattern may reduce the prevalence of symptoms related to cerebellar ataxia, headaches and migraines. Six studies report that compliance with a gluten-free dietary pattern has not been shown to have an effect on depressive symptoms; one study suggests that this may relate more to family history of depression. Evidence is less conclusive and/or limited regarding the effect of a gluten-free dietary pattern on epilepsy, anxiety, regional cerebral perfusion, hypotonia, learning disorders and disruptive behavior disorders; additional research is needed in these areas.
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
- High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
- Moderate (B) means we are moderately confident in the effect estimate;
- Low (C) means our confidence in the effect estimate is limited;
- Very Low (D) means we have very little confidence in the effect estimate.
- Ungraded means a grade is not assignable.