CD: Neurological Outcomes (2006)
What is the long-term effectiveness in people with celiac disease of following a gluten-free dietary pattern on neurological symptoms?
Several studies have reported that people with celiac disease are more likely to experience neurological symptoms such as depression, cerebellar ataxia, headaches and migraines, and neuropathy than healthy controls. Early diagnosis and compliance with a gluten-free dietary pattern may reduce the prevalence of symptoms related to cerebellar ataxia, headaches and migraines. Six studies report that compliance with a gluten-free dietary pattern has not been shown to have an effect on depressive symptoms; one study suggests that this may relate more to family history of depression. Evidence is less conclusive and/or limited regarding the effect of a gluten-free dietary pattern on epilepsy, anxiety, regional cerebral perfusion, hypotonia, learning disorders and disruptive behavior disorders; additional research is needed in these areas.
- Grade I means there is Good/Strong evidence supporting the statement;
- Grade II is Fair;
- Grade III is Limited/Weak;
- Grade IV is Expert Opinion Only;
- Grade V is Not Assignable.
Evidence Summary: What is the long-term effectiveness of following a gluten-free dietary pattern on neurological symptoms?
- Quality Rating Summary
For a summary of the Quality Rating results, click here.
- Addolorato G, Capristo E, Ghittoni G, Valeri C, Masciana R, Ancona C, Gasbarrini G. Anxiety but not depression decreases in celiac patients after one-year gluten-free diet: a longitudinal study. Scand J Gastroenterol 2001;36:502-506.
- Addolorato G, Di Giuda D, De Rossi G, Valenza V, Domenicali M, Caputo F, Gasbarrini A, Capristo E, Gasbarrini G. Regional cerebral hypoperfusion in patients with celiac disease. Am J Med 2004;116:312-317.
- Bushara KO, Goebel SU, Shill H, Goldfarb LG, Hallett M. Gluten sensitivity in sporadic and hereditary cerebellar ataxia. Ann Neurol 2001;49:540-543.
- Ciacci C, Iavarone A, Mazzacca G, De Rosa A. Depressive symptoms in adult celiac disease. Scand J Gastroenterol 1998;33(3):247-250.
- Cicarelli G, Della Rocca G, Amboni M, Ciacci C, Mazzacca G, Filla A, Barone P. Clinical and neurological abnormalities in adult celiac disease. Neurol Sci 2003; 24(5): 311-317.
- Gabrielli M, Cremonini F, Fiore G, Addolorato G, Padalino C, Candelli M, De Leo ME, Santarelli L, Giacovazzo M, Gasbarrini G, Pola P, Gasbarrini A. Association between migraine and celiac disease: results from a preliminary case-control and therapeutic study. Am J Gastroenterol 2003;98(3):625-629.
- Hadjivassiliou M, Grunewald RA, Lawden M, Davies-Jones GA, Powell T, Smith CM. Headache and CNS white matter abnormalities associated with gluten sensitivity. Neurology, 2001; 56 (3): 385-388.
- Ihara M, Makino F, Sawada H, Mezaki T, Mizutani K, Nakase H, Matsui M, Tomimoto H, Shimohama S. Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia. Intern Med 2006;45(3):135-140.
- Kieslich M, Errazuriz G, Posselt HG, Moeller-Hartmann W, Zanella F, Boehles H. Brain white-matter lesions in celiac disease: a prospective study of 75 diet-treated patients. Pediatrics 2001;108(2):e21.
- Luostarinen L, Himanen S-L, Luostarinen M, Collin P, Pirttila T. Neuromuscular and sensory disturbances in patients with well treated celiac disease. J Neurol Neurosurg Psychiatry 2003; 74: 490-494.
- Pynnonen PA, Isometsa ET, Aronen ET, Verkasalo MA, Savilahti E, Aalberg VA. Mental disorders in adolescents with celiac disease. Psychosomatics 2004; 45: 325-335.
- Volta U, De Giorgio R, Petrolini N, Stanghellini V, Barbara G, Granito A, De Ponti F, Corinaldesi R, Bianchi FB. Clinical findings and anti-neuronal antibodies in celiac disease with neurological disorders. Scand J Gastroenterol 2002;37(11):1276-1281.
- Zelnik N, Pacht A, Obeid R, Lerner A. Range of neurologic disorders in patients with celiac disease. Pediatrics 2004;113(6):1672-1676.
Search Plan and Results: CD: Neurological Symptoms 2007