Hypertension

HTN: Vitamins (2007)

• Intervention
  What is the relationship between vitamin C intake and blood pressure in healthy and hypertensive adults?

  • Conclusion

    Twelve studies investigating the effect of vitamin C on blood pressure report inconclusive findings.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What evidence suggests a relationship between vitamin C intake and blood pressure in healthy and hypertensive adults?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Beitz R, Mensink GBM, Fischer B. Blood pressure and vitamin C and fruit and vegetable intake. Annals of Nutr & Metabolism. 2003; 47: 214-220.
      • Block G. Ascorbic acid, blood pressure, and the American diet. Ann NY Acad Sci. 2002; 959: 180-187.
      • Chen J, He J, Hamm L, Batuman V, Whelton PK, Serum antioxidant vitamins and blood pressure in the United States population, Hypertension, 2002; 40: 810-816.
      • Darko D, Dornhorst A, Kelly FJ, Ritter JM, Chowienczyk PJ. Lack of effect of oral vitamin C on blood pressure, oxidative stress and endothelial function in Type II diabetes. Clinical Science, 2002; 103: 339-344.
      • Duffy SJ, Gokce N, Holbrook M, Hunter LM, Biegelsen ES, Huang A, Keaney JF, Vita JA. Effect of ascorbic acid on conduit vessel endothelial dysfunction in patients with hypertension. Am J Physiol Heart Circ Physiol. 2001; 280: H528-H534. 
      • Eskurza I, Monahan KD, Robinson JA, Seals DR. Ascorbic acid does not affect large elastic artery compliance or central blood pressure in young and older men. Am J Physiol Heart Circ Physiol. 2004; 286: H1528-H1534.
      • Farvid MS, Jalali M, Siassi F, Saadat N, Hosseini M, The impact of vitamins and/or mineral supplementation on blood pressure in type 2 diabetes, J Am College of Nutrition. 2004, 23: 272-279.
      • Fotherby MD, Williams JC, Forster LA, Craner P, Ferns GA. Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons. J Hypertension. 2000; 18: 411-415.
      • Kim MK, Sasaki S, Sasazuki S, Okubo S, Hayashi M, Tsugane S. Lack of long-term effect of vitamin C supplementation on blood pressure. Hypertension. 2002; 40: 797-803.
      • Magen E, Viskoper R, Mishal J, Priluk R, Berezovsky A, Laszt A, London D, Yosefy C. Resistant arterial hypertension and hyperlipidemia: Atorvastatin, not vitamin C, for blood pressure control. Isr Med Assoc J. 2004; 6: 742-746.
      • Mullan BA, Young IS, Fee H, McCance DR. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes. Hypertension. 2002; 40: 804-809.
      • Schutte AE, Huisman HW, Oosthuizen W, vanRooyen JM, Jerling JC, Cardiovascular effects of oral supplementation of vitamin C, E and folic acid in young healhy males, Int J Vitam Nutr Res. 2004; 74 (4): 285-293.
  • Search Plan and Results: Vitamin C 2005
     
  What is the relationship between vitamin E intake and blood pressure in healthy and hypertensive adults?

  • Conclusion

    Six studies investigating the effect of vitamin E on blood pressure report inconclusive findings.

  • Grade: III
    • Grade I means there is Good/Strong evidence supporting the statement;
    • Grade II is Fair;
    • Grade III is Limited/Weak;
    • Grade IV is Expert Opinion Only;
    • Grade V is Not Assignable.
    • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
    • Moderate (B) means we are moderately confident in the effect estimate;
    • Low (C) means our confidence in the effect estimate is limited;
    • Very Low (D) means we have very little confidence in the effect estimate.
    • Ungraded means a grade is not assignable.
  • Evidence Summary: What evidence suggests a relationship between vitamin E intake and blood pressure in healthy and hypertensive adults?
    • Detail
    • Quality Rating Summary
      For a summary of the Quality Rating results, click here.
    • Worksheets
      • Boshtam M, Morteza R, Kamran S, Sarraf-Zadegan N, Vitamin E can reduce blood pressure in mild hypertensives, Int J Vitamin Nutr Res. 2002, 72 (5): 309-314.
      • Chen J, He J, Hamm L, Batuman V, Whelton PK, Serum antioxidant vitamins and blood pressure in the United States population, Hypertension, 2002; 40: 810-816.
      • Farvid MS, Jalali M, Siassi F, Saadat N, Hosseini M, The impact of vitamins and/or mineral supplementation on blood pressure in type 2 diabetes, J Am College of Nutrition. 2004, 23: 272-279.
      • Mishra GD, Malik NS, Paul AA, Wadsworth MEJ, Bolton-Smith C, Childhood and adult dietary vitamin E intake and cardiovascular risk factors in mid-life in the 1946 British Birth Cohort, Eur J of Clin Nutr. (2003) 57: 1,418-1,425.
      • Palumbo G, Avanzini F, Alli C, et al, Effects of Vitamin E on Clinic and Ambulatory Bood Pressure in Treated Hypertensive Patients, Am J Hypertension. 2000, 13: 564-567.
      • Schutte AE, Huisman HW, Oosthuizen W, vanRooyen JM, Jerling JC, Cardiovascular effects of oral supplementation of vitamin C, E and folic acid in young healhy males, Int J Vitam Nutr Res. 2004; 74 (4): 285-293.
  • Search Plan and Results: Vitamin E 2005