Omega-3 Fatty Acid Supplementation

Author and Year:
Masson S, Marchioli R et al, 2013
PubMed ID:
Article Title:
Plasma N-3 polyunsaturated fatty acids in chronic heart failure in the GISSI-Heart Failure Trial: Relation with fish intake, circulating biomarkers and mortality.
Masson S, Marchioli R, Mozaffarian D, Bernasconi R, Milani V, Dragani L, Tacconi M, Marfisi R, Borgese L, Cirrincione V, Febo O, Nicolis E, Maggioni A, Tognoni G, Tavazzi L, Latini R
American Heart Journal
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Study Design:
Cross-Sectional Study
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Inclusion Criteria:
Only available in original study. Chronic heart failure of New York Heart Association class II-IV, irrespective of cause and left ventricular ejection fraction.
Exclusion Criteria:
Only available in original study.
Research Purpose:
In the present substudy of the GISSI-HF trial, we measured phospholipid N-3 PUFA at two time-points, at baseline and after three-month N-3 PUFA or placebo supplementation, to assess (1) their independent relation to patients'' dietary habits and to biomarkers of inflammatory, cardiac and metabolic function; (2) whether baseline concentrations of N-3 PUFA predict mortality in a fully adjusted multivariable model; and (3) the effects of supplementation of N-3 PUFA.
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Please specify names of funders:
The biomarker substudy of the GISSI-Heart Failure trial has received support by research grants from Società Prodotti Antibiotici (Italy), Pfizer, Sigma Tau and AstraZeneca and, in part, by a grant from Regione Lombardia “Progetto Ricerca Indipendente 2010: Caratterizzazione della pentraxina lungs PTX3 come biomarcatore in patologia cardiovascolare.”