HTN: Medical Nutrition Therapy (2022-24)
Author and Year:
Malta D, Arcand J, Ravindran A, et al. 2016
PubMed ID:
Article Title:
Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system.
Authors:
Malta D, Arcand J, Ravindran A, Floras V, Allard J, Newton G
Journal:
American Journal of Clinical Nutrition
Year of publication:
2016
Volume:
104
Issue:
4
Page numbers:
990-994
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
Ages 18-25; stable without hospitalizations in the 3 months before study entry. All recruited participants were receiving hypertension treatment with >/=1 ACEi or ARB, and all had a potassium intake <2500 mg/d, as estimated by a 24-hour recall at the time of recruitment.
Exclusion Criteria:
Exclusion criteria included treatment with insulin, loop and potassium-sparing diuretics, a serum potassium concentration >5.0 mmol/L, and a serum creatinine concentration >130 mmol/L.
Research Purpose:
The purpose of this study was to assess the effect of increasing dietary potassium on serum potassium concentration in hypertensive individuals with normal renal function treated with an ACEi or ARB. We hypothesized that an increase in dietary potassium would not provoke hyperkalemia in this population despite treatment with either an ACEi or ARB.
Blinding efforts:
See Risk of Bias.
Study Location:
Canada
Source(s) of Funding:
Not reported
Please specify names of funders: