Whelton et al 1992

1586398

The Effects of Nonpharmacologic Interventions on Blood Pressure of Persons With High Normal Levels

The Trials of Hypertension Prevention Collaborative Research Group

Journal of the American Medical Association

1992

267

9

1213-1220

Randomized Controlled Trial

Some concerns

The target population consisted of healthy men and women, aged 30 through 54 years, who had high normal DBP and were not taking antihypertensive drugs for the prior 2 months. The BP eligibility level was based on three measurements at each of three screening visits (SV), between 10 and 30 days apart, with inclusion limits based on cumulative averages of all readings through that visit, as follows: SVI, 75 through 97 mm Hg; SV2, 77 through 94 mm Hg; and SV3 (baseline), 80 through 89 mm Hg.

Candidates were excluded if they had (1) clinical or laboratory evidence of cardiovascular or other life threatening or disabling diseases, (2) conditions that would require or contraindícate any of the interventions, or (3) evidence of unwillingness or inability to comply with intervention or data collection procedures.

1) to test the short term effect on BP of selected nutritional and behavioral interventions, and (2) to determine the feasibility of a long-term clinical trial of methods for reducing the incidence of hypertension.

See Risk of Bias.

United States

Government

National Heart, Lung, and Blood Institute, National Institutes of Health