Lindstrom J, Peltonen M, et al, 2013

23093136

Improved lifestyle and decreased diabetes risk over 13 years: long-term follow-up of the randomised Finnish Diabetes Prevention Study (DPS).

Lindström J, Peltonen M, Eriksson J, Ilanne-Parikka P, Aunola S, Keinänen-Kiukaanniemi S, Uusitupa M, Tuomilehto J

Diabetologia

2013

56

2

284-293

Randomized Controlled Trial

Some concerns

BMI over 25 kg/m2; age 40–64 years ; impaired glucose tolerance on the basis of the mean values of two oral glucose tolerance tests with 2-h plasma glucose 7.8-11.0 mmol/L; fasting blood glucose of <7.8 mmol/L

Previous diagnosis type 2 diabetes mellitus - other than gestational diabetes; persons involved regularly in a vigorous exercise programme receiving treatment to lower blood glucose; persons with chronic disease making a 6-year survival improbable; medical characteristics likely to interfere with participation in the study; subjects with unbalanced clinical conditions, such as thyroid and liver disease (can interfere with glucose metabolism).

The aim of this study was to investigate whether diabetes incidence was still reduced after a median of 13 years from the initiation of lifestyle intervention. In addition, we explored the changes in lifestyle (diet and physical activity)and clinical variables (body weight, fasting and 2 h plasma glucose after an OGTT) during and after the active intervention period and analyzed the association between life-style changes and diabetes risk.

Finland

Government, University/Hospital, Not-for-profit

Academy of Finland (128315, 129330) Ministry of Education Finnish Diabetes Research Foundation Finnish Foundation for Cardiovascular Research Unilever Yrjo Jahnsson Foundation Juho Vainio Foundation Novo Nordisk Foundation Competitive Research Funding from Tampere, Kuopio and Oulu University Hospitals

Finnish Diabetes Prevention Study, NCT00518167