NPA-GP: Glucose Outcomes (2021)

Author and Year:
Lindstrom J, Peltonen M, et al, 2013
PubMed ID:
Article Title:
Improved lifestyle and decreased diabetes risk over 13 years: long-term follow-up of the randomised Finnish Diabetes Prevention Study (DPS).
Lindström J, Peltonen M, Eriksson J, Ilanne-Parikka P, Aunola S, Keinänen-Kiukaanniemi S, Uusitupa M, Tuomilehto J
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
BMI over 25 kg/m2; age 40–64 years ; impaired glucose tolerance on the basis of the mean values of two oral glucose tolerance tests with 2-h plasma glucose 7.8-11.0 mmol/L; fasting blood glucose of <7.8 mmol/L
Exclusion Criteria:
Previous diagnosis type 2 diabetes mellitus - other than gestational diabetes; persons involved regularly in a vigorous exercise programme receiving treatment to lower blood glucose; persons with chronic disease making a 6-year survival improbable; medical characteristics likely to interfere with participation in the study; subjects with unbalanced clinical conditions, such as thyroid and liver disease (can interfere with glucose metabolism).
Research Purpose:
The aim of this study was to investigate whether diabetes incidence was still reduced after a median of 13 years from the initiation of lifestyle intervention. In addition, we explored the changes in lifestyle (diet and physical activity)and clinical variables (body weight, fasting and 2 h plasma glucose after an OGTT) during and after the active intervention period and analyzed the association between life-style changes and diabetes risk.
Blinding efforts:
Study Location:
Source(s) of Funding:
Government, University/Hospital, Not-for-profit
Please specify names of funders:
Academy of Finland (128315, 129330) Ministry of Education Finnish Diabetes Research Foundation Finnish Foundation for Cardiovascular Research Unilever Yrjo Jahnsson Foundation Juho Vainio Foundation Novo Nordisk Foundation Competitive Research Funding from Tampere, Kuopio and Oulu University Hospitals
Trial Name if applicable:
Finnish Diabetes Prevention Study, NCT00518167