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NPA-GP: Adverse Events (2021)

Author and Year:

Campbell K, Foster-Schubert K, et al, 2012

PubMed ID:

22614972

Article Title:

Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial.

Authors:

Campbell K, Foster-Schubert K, Alfano C, Wang C, Wang C, Duggan C, Mason C, Imayama I, Kong A, Xiao L, Bain C, Blackburn G, Stanczyk F, McTiernan A

Journal:

Journal of Clinical Oncology

Year of publication:

2012

Volume:

Issue:

Page numbers:

2314-26

Study Design:

Randomized Controlled Trial

Risk of Bias Assessment Rating:

Some concerns

Inclusion Criteria:

Participants were postmenopausal (no menstrual cycles for >/= 1 year or follicle-stimulating hormone level of >23.0 IU/L for women 50 to 59 years of age without a uterus), age 50 to 75 years, body mass index > /= 25.0 kg/m2 (>/= 23.0 kg/m2 if Asian-American), and participating in less than 100 minutes/wk in moderate-intensity physical activity.

Exclusion Criteria:

Exclusion criteria included use of estrogen, progesterone, or testosterone hormones (past 3 months); history of breast cancer or other serious medical conditions; diabetes, fasting glucose >/= 126 mg/dL, or use of diabetes medications; more than two alcohol drinks/d; current smoker; or current use of weight loss medications or programs.

Research Purpose:

To evaluate the individual and combined effects of a reduced-calorie weight loss diet and exercise on serum sex hormones in overweight and obese postmenopausal women.

Blinding efforts:

Study Location:

USA

Source(s) of Funding:

Government

Please specify names of funders:

The Nutrition and Exercise for Women (NEW) trial was supported by R01 CA105204-01A1 from the National Cancer Institute (NCI).

Trial Name if applicable:

NEW