CRDA: Other Outcomes (2023)

Author and Year:
Properzi C, O'Sullivan T, et al. 2018
PubMed ID:
Article Title:
Ad Libitum Mediterranean and Low-Fat Diets Both Significantly Reduce Hepatic Steatosis: A Randomized Controlled Trial.
Properzi C, O'Sullivan T, Sherriff J, Ching H, Jeffrey G, Buckley R, Tibballs J, MacQuillan G, Garas G, Adams L
Hepatology (Baltimore, MD)
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Some concerns
Inclusion Criteria:
Diagnosis of NAFLD, with HS quantified as >5.5% as determined by magnetic resonance spectroscopy (MRS); average alcohol consumption of <20 g/day or 140 g/week for females or <30 g/day or 210 g/week for males.
Exclusion Criteria:
Secondary causes of NAFLD (e.g., medication induced); unstable body weight (variation >5% within the preceding 3-months period); current use of weight loss medications (e.g., Orlistat); current use of pioglitazone; other liver disease (viral hepatitis, autoimmune or cholestatic liver disease, Wilson’s disease, hemochromatosis, or alpha-1 anti-trypsin deficiency); unstable diabetes (HbA1c >8.5%); decompensated cirrhosis (international normalized ratio >1.3, platelets 20 mmol/L, albumin <35 g/L, ascites, or hepatic encephalopathy); renal failure; malignancy (aside from skin cancer); inability to provide informed consent; claustrophobia preventing MRS examination; current smoking; atrial fibrillation preventing SphygmoCor assessment; pregnancy or lactation.
Research Purpose:
To guide optimal nutritional treatment for NAFLD and examine the efficacy of focusing upon altering nutrient profiles without body weight loss.
Blinding efforts:
Study Location:
Source(s) of Funding:
Government, Industry
Please specify names of funders:
The author received an Australian Government Research Training Program Scholarship. Cobram Estate Olive Oil donated a portion of the olive oil supplied on the Mediterranean intervention.