CRDA: Lipid Outcomes (2023)

Author and Year:
Abbate M, Mascaro C, et al. 2021
PubMed ID:
Article Title:
Energy Expenditure Improved Risk Factors Associated with Renal Function Loss in NAFLD and MetS Patients.
Abbate M, Mascaró C, Montemayor S, Barbería-Latasa M, Casares M, Gómez C, Angullo-Martinez E, Tejada S, Abete I, Zulet M, Sureda A, Martínez J, Tur J
Year of publication:
Page numbers:
Study Design:
Randomized Controlled Trial
Risk of Bias Assessment Rating:
Low risk
Inclusion Criteria:
Male and female; aged 40-60 years; previous diagnosis of NAFLD by liver ultrasound; BMI between 27-40 kg/m2; presenting at least three of the five MetS traits: (1) BMI >30 kg/m2 or increased waist circumference: >/=94 cm in males and >/=80 cm in females; (2) triglycerides (TG) levels >/=150 mg/dL (1.7 mmol/L), or specific treatment; (3) reduced high-density lipoprotein cholesterol (HDL-C): (4) raised blood pressure >/=130 or diastolic BP >/=85 mm Hg, or treatment of previously diagnosed HTN; (5) raised fasting plasma glucose (FPG) >=100 mg/dL (5.6 mmol/L), or previously diagnosed type 2 diabetes (T2DM).
Exclusion Criteria:
Previous cardiovascular disease; liver disease (other than NAFLD); cancer or a history of malignancy in previous 5 years; haemochromatosis; previous bariatric surgery; non-medicated depression; alcohol and drug abuse; pregnancy; pPrimary endocrinological diseases (other than non-medicated hypothyroidism); concomitant therapy with steroids; inability to provide informed consent.
Research Purpose:
To assess the efficacy of lifestyle intervention on the reduction of liver fat content and MetS, along with whether such reductions would influence renal outcomes.
Blinding efforts:
Randomization was performed by a dedicated person and blinded to all staff and the principal investigator
Study Location:
Source(s) of Funding:
Government, Foundation
Please specify names of funders:
Fundació La Marató TV3 (Spain) project ref. 201630.10. Instituto de Salud Carlos III through the Fondo de Investigación para la Salud (Projects PI14/00636 and PI17/01827. CIBEROBN CB12/03/30038 (Proyecto Intramural CIBER OBN18PI03). Health Department of the Government of Navarra (61/2015). Grant of support to research groups no. 35/2011 and 23/2012 (Balearic Islands Government), which are co-funded by the European Regional Development Fund. Other funding received: EU-COST Action CA1.